Week 16 NFL Picks: Green Bay Back Might be NFC Favorites

Week 16 NFL Picks: Green Bay Back Might be NFC Favorites

Check out our best NFL bets for Week 16 of the 2021 regular season.

Entering Week 16 of the 2021 NFL season, it is getting tougher and tougher for the best betting sites on the NFL to deliver concrete grips on their lines. Rosters are being ravaged by a surge of COVID-19 cases, which has made it difficult to discern the number of players who will be available on a weekly basis. 

Fortunately, the latest injury and health-and-safety reports are in. That gives us enough information to drop Week 16 NFL picks, wherein we'll ponder the futures of both the Green Bay Packers as NFC favorites and the slumping Buffalo Bills

Here are the latest Week 16 NFL betting odds, courtesy from the folks over at BetOnline:

FavoriteBetOnlineBetOnlineUnderdog
San Francisco 49ers-183+163Tennessee Titans
Green Bay Packers-350+280Cleveland Browns
Arizona Cardinals-110-110Indianapolis Colts
Tampa Bay Buccaneers-480+390Carolina Panthers
Los Angeles Chargers-436+327Houston Texans
Atlanta Falcons-261+208Detroit Lions
Cincinnati Bengals-135+115Baltimore Ravens
Los Angeles Rams-164+135Minnesota Vikings
New York Jets-140+120Jacksonville Jaguars
New England Patriots-135+115Buffalo Bills
Las Vegas Raiders-122+101Denver Broncos
New Orleans Saints-165+145Miami Dolphins
Dallas Cowboys-538+389Washington Football Team

In light of the NFL's COVID-19 issues, we cannot stress this enough: Whether you're wagering on games, NFL props or betting on the Super Bowl, it's mega-important to quadruple-check all NFL odds. Linemakers are moving their NFL betting odds more often and to starker degrees as they react to the latest breaking news. Make sure you're staying on top of those changes.

Consider going through our reviews of the top online sportsbooks to help you grapple with an ever-shifting NFL betting landscape. We researched the most reliable sports betting sites so you don't have to. Take advantage of it.

2021 Week 16 NFL Predictions

Please note that all of our Week 16 NFL picks are accurate as of Wednesday, December 22. We sound like a broken record, but it's crucial to note given all the health-and-safety issues currently plaguing the league.

If you're placing your Week 16 NFL predictions later than this, chances are you'll need to make these NFL picks against different NFL betting lines.

Are Packers Now Favorites to Come Out of NFC?

After seeing both the Tampa Bay Buccaneers and the Arizona Cardinals stumble in Week 15, lots of folks are asking whether the Aaron Rodgers-led Packers should be favorites to come out of the NFC.

Our answer is an overwhelming, resounding...no.

This shouldn't really surprise anyone. The Packers have done a nice job getting to 11 victories before Week 16 despite navigating an early offensive slump and a later-season absence form Rodgers. But the offense is so vulnerable outside of his heroics, and they haven't needed to play against an especially difficult schedule.

Green Bay's good schedule fortune will continue in Week 16 against the Cleveland Browns. They would normally pose a tougher challenge if everyone were available, but their quarterback situation is currently in shambles due to a slew of COVID-19 cases. If the Packers don't win this Christmas Day affair, they'll need to take a long look in the mirror.

OSB Prediction: Green Bay Packers (-350)

Green Bay Packers To beat the Cleveland Browns
-350
BetOnline

Bills Need to Beat Patriots...But Will They?

Without question, the Bills need to pick up this victory against the New England Patriots if they have any hope of recapturing the lead in the AFC East. We believe they will get it.

Not only has Buffalo's offense returned to form over the past two weeks, thanks in large part to quarterback Josh Allen, but the Patriots offense is slogging through a slump now that the scouting report has dropped on rookie QB Mac Jones.

Playing in New England may change the calculus a bit, but the Bills are far from strangers to battling in cold weather. They can steal this one.

OSB Prediction: Buffalo Bills (+115)

Buffalo Bills To beat the New England Patriots
+115
BetOnline

Cardinals Bounce Back vs. Colts

The Cardinals should absolutely be lampooned for falling to the then-winless Detroit Lions in Week 16. Putting up just 12 points against that defense is criminally bad. But we shouldn't expect it to happen again.

Sure, the Indianapolis Colts are 7-2 since beginning the season 1-4. But their third-ranked offense isn't as dynamic as it seems. They need running back Jonathan Stewart to carry a lion's share of the workload, and Arizona has done a better job defending against ground games in recent weeks.

OSB Prediction: Arizona Cardinals (-110)

Arizona Cardinals To beat the Indianapolis Colts
-110
BetOnline

Jags Notch a Win Over Jets

For the life of us, we cannot figure out why the Jacksonville Jaguars are underdogs against the New York Jets.

It is difficult to come up with lines for two really bad squads, but the Jaguars clearly have the higher ceiling if they get a good game from rookie quarterback Trevor Lawrence. On top of that, teams tend to play a tad better after changing head coaches, and the late-season dismissal of Urban Meyes could spark something of a mini-turnaround for a Jacksonville team that, despite its record, is not absent offensive talent.

OSB Prediction: Jacksonville Jaguars (+120)

Jacksonville Jaguars To beat the New York Jets
+120
BetOnline

Tampa Bay Finds a Way Against Carolina

The New Orleans Saints defense held the Bucs offense to zero points in Week 15. That is not a typo, even though it reads like one. 

Ask yourself this: Do you really expect Tom Brady and crew, who rank in the top five of points per game this season, to lay another egg? Especially when playing a barely average Carolina Panthers passing defense?

That's what we thought.

OSB Prediction: Tampa Bay Buccaneers (-480)

Tampa Bay Buccaneers To beat the Carolina Panthers
-480
BetOnline

Take a look at this list of the top online sportsbooks so you can decide which one to use for all of your NFL betting:

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