2021 NFL Division Winner Picks

2021 NFL Division Winner Picks

'Tis the season to dig into NFL futures. But while the vast majority of time around these big-picture bets is dedicated to win totals and Super Bowl odds, let us not forget about the most important regular-season race taking place within each division.

Yes, the rumors are true: It's time for our 2021 NFL winner picks. 

Let's start with the latest NFL odds for the favorites to win each division, brought to you by BetOnline:

NFL DivisionBetOnlineBetOnlineBetOnlineBetOnline
NFC EastDallas Cowboys (+165)Washington (+180)New York Giants (+325)Philadelphia Eagles (+625)
NFC NorthGreen Bay Packers (-150)Minnesota Vikings (+220)Chicago Bears (+575)Detroit Lions (+2000)
NFC SouthTampa Bay Buccaneers (-225)New Orleans Saints (+375)Atlanta Falcons (+800)Carolina Panthers (+950)
NFC WestSan Francisco 49ers (+195)Los Angeles Rams (+205)Seattle Seahawks (+275)Arizona Cardinals (+475)
AFC EastBuffalo Bulls (-160)New England Patriots (+340)Miami Dolphins (+350)New York Jets (+1800)
AFC NorthBaltimore Ravens (+140)Cleveland Browns (+140)Pittsburgh Steelers (+425)Cincinnati Bengals (+1200)
AFC SouthTennessee Titans (-130)Indianapolis Colts (+180)Jacksonville Jaguars (+600)Houston Texans (+2500)
AFC WestKansas City Chiefs (-250)Los Angeles Chargers (+500)Denver Broncos (+525)Las Vegas Raiders (+1400)

Make sure to double-check these lines before committing to a specific wager. These NFL betting odds will move at BetOnline and other online sportsbooks before Week 1 and as the 2021 regular season unfolds.

new york giants odds

2021 NFL Division Predictions

With eight divisions to predict, we don't have time to waste. We'll be moving quickly through all of our selections.

Don't worry, though. We won't skimp on the reasoning when it comes to controversial divisions. 

For your edification, we'll begin with the four NFC conferences and run our way through the four AFC conferences.

NFC East

  • Dallas Cowboys (+165)
  • Washington (+180)
  • New York Giants (+325)
  • Philadelphia Eagles (+625)

Going with the Cowboys when we haven't seen quarterback Dak Prescott play in over a year no doubt carries some risk.

The alternative, though, is investing in the carousel under center of Washington or trusting the New York Giants to make a leap. So, yeah, Dallas it is.

OSB Prediction: Dallas Cowboys (+165)

Dallas Cowboys To win the NFC East

NFC North

  • Green Bay Packers (-150)
  • Minnesota Vikings (+220)
  • Chicago Bears (+575)
  • Detroit Lions (+2000)

Maybe you can talk yourself into the Vikings if you think Kirk Cousins regains some of his magic under center from 2019. We're not there.

Anyway, even if he does, Aaron Rodgers is still an MVP candidate the last we checked. It doesn't make sense to bet against him knowing he'll finish the season in Green Bay.

OSB Prediction: Green Bay Packers (-150)

Green Bay Packers To win the NFC North

NFC South

  • Tampa Bay Buccaneers (-225)
  • New Orleans Saints (+375)
  • Atlanta Falcons (+800)
  • Carolina Panthers (+950)

There is no path to picking anyone other than the Bucs unless you think Tom Brady will suffer an injury. But you can't make these early projections by assuming something like that.

Perhaps the Saints would have a crack at it if Drew Brees didn't retire. But he did.

OSB Prediction: Tampa Bay Buccaneers (-225)

Tampa Bay Buccaneers To win the NFC South

NFC West

  • San Francisco 49ers (+195)
  • Los Angeles Rams (+205)
  • Seattle Seahawks (+275)
  • Arizona Cardinals (+475)

Most will gravitate toward the Niners or Rams here. We get it. Their defenses have a chance to rank in the top seven of points allowed per game and can smother you from all angles.

Still, the Seahawks have the most potent offense of anyone in this division. We're putting our faith in Russell Wilson.

seahawks odds

OSB Prediction: Seattle Seahawks (+275)

Seattle Seahawks To win the NFC West

AFC East

  • Buffalo Bills (-160)
  • New England Patriots (+340)
  • Miami Dolphins (+350)
  • New York Jets (+1800)

Taking the Patriots is an interesting value you play if you think Cam Newton will have a bounce-back year. And yet, we can't even be sure he'll be given enough time to establish himself with Mac Jones waiting to take over.

After New England, nobody else poses a threat to the Bills. They are a two-way beast, and the Josh Allen-Stefon Diggs one-two punch is among the most dangerous QB-WR duos in football.

OSB Prediction: Buffalo Bills (-160)

Buffalo Bills To win the AFC East

AFC North

  • Baltimore Ravens (+140)
  • Cleveland Browns (+140)
  • Pittsburgh Steelers (+425)
  • Cincinnati Bengals (+1200)

It feels like oddsmakers are overlooking the Steelers.

Sure, Ben Roethlisberger is 39, and the defense has their fair share of issues. But Pittsburgh just won 12 games last season and didn't obliterate the core. As long as Big Ben stays healthy, this feels like a 10-win team—and that should be enough to eke out an edge over the Browns and Ravens.

OSB Prediction: Pittsburgh Steelers (+425)

Pittsburgh Steelers To win the AFC North

AFC South

  • Tennessee Titans (-130)
  • Indianapolis Colts (+180)
  • Jacksonville Jaguars (+600)
  • Houston Texans (+2500)

Imagine not picking the Titans.

Seriously, there is no reason to bet against them. Rayn Tannehill continues to be one of the most underrated quarterbacks in the game, Derrick Henry remains the best running back alive, and they just traded for star wideout Julio Jones.

From where we're standing, Tennessee at -130 is a gift from the oddsmakers to you.

OSB Prediction: Tennessee Titans (-130)

Tennessee Titans To win the AFC South

AFC West

  • Kansas City Chiefs (-250)
  • Los Angeles Chargers (+500)
  • Denver Broncos (+525)
  • Las Vegas Raiders (+1400)

You could bet against the Chiefs to win the AFC West. But why?

Short of Patrick Mahomes falling off the face of the Earth, this is their division to lose. We recommend hopping on their odds while they're still paying out better than -1000.

OSB Prediction: Kansas City Chiefs (-250)

Kansas City Chiefs To win the AFC West

Check out this list of the top online sportsbooks so you can decide which ones to use for all your NFL betting:


Meet the author

Eric Uribe

Eric has been passionate about sports since he was 10 years old. He brings over 10 years of sports journalism experience to his expert coverage of sports betting. Hailing from the US, Eric leverages his diverse expertise covering sports at all levels – from high sch...

Online Sports Betting may receive compensation if you sign up through our links. Rest assured, we avoid biases and provide honest opinions on sportsbooks. Read more here.