2022 NFL Week 6 Picks: San Francisco 49ers Defense will Dominate Atlanta Falcons

2022 NFL Week 6 Picks: San Francisco 49ers Defense will Dominate Atlanta Falcons

It may not be reflected in their 3-2 record to open the 2022 NFL season, but the San Francisco 49ers are on what could be a meteoric rise. And their Week 6 matchup against the Atlanta Falcons should help show us all why.

Are we saying you should go hammer the Niners' odds to win the Super Bowl right now? Not exactly. They have questions on offense. But the San Francisco defense is a special brand of terrifying. It's elite by every imaginable metric and doesn't include any discernible weaknesses. If they can get a semblance of consistency from their offense, then yes, we may very well be looking at a Super Bowl candidate.

But that's an issue to tackle down the line. Right now, let's have a look at the latest NFL online betting odds for the 49ers vs. Falcons entering Week 6, courtesy of our friends from BetUS:


Please continue rechecking these NFL betting odds until you actually finalize your wager. The San Francisco 49ers and Atlanta Falcons are set to meet on Sunday, October 16, at 1 p.m EST. Since our Niners vs. Falcons betting odds are accurate entering Tuesday, October 11, this means they'll have plenty of time to move between then and the opening kickoff.

As an important aside: Anyone still searching for a place to bet on the NFL in 2022 should head over to our reviews of the top online sportsbooks as soon as possible. With all the information we include, you will be able to join one of the best online NFL betting sites for 2022 in no time at all!

It's officially time for our Niners vs. Falcons predictions. And remember: Our best NFL Week 6 bets don't just seek to identify the outright winner. We're betting on the point spread for San Francisco vs. Atlanta, as well as the over/under!

The Atlanta Falcons Stand No Chance Against the San Francisco 49ers Defense

Kudos to the Falcons for propping up a 16th-place offense this season. Seriously. When they traded quarterback Matt Ryan over the offseason and pivoted into the Marcus Mariota era, everyone thought they'd have one of the worst attacks in existence. Their capacity to consistently clear 24 points per game is truly impressive.

Then again, it's also under siege.

Atlanta is averaging just 19 points per game over the past two weeks. Now, they go up against a Niners defense allowing just 12.2 points per game—best mark in the NFL.

Finding a weak point for Atlanta to attack is difficult. It might be impossible. San Francisco's defense is dominating on all cylinders. They rank second in net yards allowed per passing attempt and first in yards surrendered per rushing attempt. That is bonkers.

Contrarian bettors are free to doubt the Niners offense under quarterback Jimmy Garoppolo. We would even encourage it. But the Niners have totaled 61 points across their past two games, and Atlanta currently fields one of the seven worst passing defenses in the business. San Francisco shouldn't have any trouble scoring juuust enough to support their defense.

OSB Prediction: San Francisco 49ers (-235)

San Francisco 49ers To beat the Atlanta Falcons

Why Betting the Point Spread in 49ers vs. Falcons Could Be Touch-and-Go

Below you can find the latest point spread betting odds for the 49ers vs. Falcons matchup in Week 6: 

  • San Francisco 49ers, -5.5 (-106)
  • Atlanta Falcons, +5.5 (-114)

Theoretically, this point spread is dangerous if you're investing in the Niners. They haven't cobbled together the offensive consistency necessary to suggest they're built to routinely win by a touchdown or more.

And yet, all three of San Francisco's wins have come by at least 15 points. In fact, their average margin of victory this season is over 19.6 points.

You don't need that average to hold against the Falcons. But knowing how many extra bites at the apple San Francisco's defense gives their offense, you can trust the Niners will have so many opportunities to score that, well, they'll actually score.

OSB Prediction: San Francisco 49ers, -5.5 (-106)

San Francisco 49ers To cover the spread vs. the Atlanta Falcons

Will San Francisco and Atlanta Generate Enough Offense to Cover the Over in Week 6?

Here are the latest over/under betting odds for Niners vs. Falcons: 

  • Over 43.5 (-110)
  • Under 43.5 (-110)

Linemakers have posted a lot of sub-45-point over/under markers this week. Virtually all of them are difficult to figure out.

Atlanta and San Francisco appears easy at first glance. Both rank smack dab in the middle of points per game. However, that still means they average over 45 points per game combined. That would be enough to take us to the over, albeit just barely. Even more complicated, the Niners have toppled their past two opponents, clearing at least 27 points in each of the past two weeks.

Go ahead and pencil in another stellar offensive performance for the Niners. We're still taking the under. Their defense is built to shut down the way that the Falcons play. Atlanta doesn't have a lot of variety to begin with, and Mariota is only completing 57 percent of his passes. This could be a game that ends 27-10 in the Niners' favor, as far as we're concerned. And if that doesn't do it for you, perhaps you'll feel good knowing the under has hit in four of the Falcons' five games so far.

OSB Prediction: Under 43.5 (-110)

49ers and Falcons To score under 43.5 points combined

Take a look at this list of the top online sportsbooks so you can decide which one to use for all of your 2022 NFL betting:

Meet the author

Dan Favale

Dan is a sports betting writer who can tackle any topic from presidential elections to changes in the sports betting legislation federally and on the state level. He also writes picks for NFL.