• What: WBO and WBA Strawweight Title
  • Who: Oscar Collazo (c) vs Jayson Vayson
  • When: Saturday, September 20, 2025
  • Where: Fantasy Springs Resort and Casino, Indio, California
  • Watch: DAZN, 10:00 pm ET

World strawweight title holder Oscar Collazo is unbeaten, and in the boxing betting odds, the feeling is that he'll be retaining that status as he defends his WBO and WBA belts against challenger Jayson Vayson.

Oddsmakers are setting the champ as a massive -1200 favorite in the boxing odds to retain his title. Vayson is offered at +650 underdog odds.

Let’s look at the latest boxing betting lines for this bout. Remember, the odds are always subject to change.

WBA & WBO Strawweight Title OddsThe PickBovadaBetUSBetOnline
Oscar Collazo vs Jayson VaysonCollazo-1200-1200-1100

In this article, OSB will review each fighter, predict the winner of the matchup, and provide additional notes and information on boxing picks and betting.

Fight Overview: Oscar Collazo vs Jayson Vayson

Vayson's manager Brico Santig pulled his fighter out of a bout against Regie Suganob when the opportunity arose for a chance to fight Collazo for the title. Collazo has already successfully defended his strawweight title belts on six occasions.

Fighter Spotlight: Oscar Collazo

A 28-year-old Puerto Rican, Collazo (12-0), dethroned WBO strawweight champion Melvin Jerusalem to claim that title belt in January 2023. He added the WBA title by knocking out champion Knockout CP Freshmart in a November 2024 bout. Collazo is also the Ring Magazine champion of this weight class.

Earlier this year, Collazo defended both strawweight title belts, dispatching 13-2-1 Edwin Cano Hernandez via a seventh-round stoppage resulting from a body shot. He also shows a unanimous decision victory over former world champion Vic Saludar on his resume.

Fighter Spotlight: Jayson Vayson

Vayson (14-1-1) is seeking to make history by dethroning Collazo. If he wins, it will mark the first time in boxing history that an entire weight class will be ruled by Filipino fighters. Jerusalem is the current WBC titleholder. Pedro Taduran is the IBF champion.

Vayson has won his past four fights. Ranked No. 10 by the WBA and No. 7 by the WBO, Vayson first fought his way into the world rankings by stopping former world champion Ryuya Yamanaka via a second-round knockout in their December 2023 bout. That victory earned Vayson the WBO Asia Pacific light-flyweight title. He is also the ABF flyweight title holder

Best World Strawweight Title Prop Bets

In the boxing betting props on this bout, the total rounds are set at 8.5. You'll get -115 odds whichever way you bet this play, but the under might be worth a go. Six of Collazo's last seven fights didn't get to the eighth round. On the other hand, only two of Vayson's past seven fights didn't go over 8.5 rounds.

The odds of the fight going the distance are set at +200. Wager on the fight not to go the distance, and the betting line is -275. Colazzo to win by knockout, technical knockout, or disqualification comes with boxing betting odds of -230. The Puerto Rican fighter is +240 to win via decision or technical decision.

Vayson is set at odds of +1100 to win by knockout, technical knockout, or disqualification. You'll be given +1400 odds if you bet the Filipino boxer to win by decision or technical decision. A draw or technical draw comes with a betting line of +2500.

Best Bet To Win Strawweight Title

This will be Vayson's seventh successive fight outside the Philippines, but it's his first bout in North America. All of his previous fights were in Asia or the United Arab Emirates. He's also cut from 127 to 105 pounds in five months to make weight for this bout.

Oscar Collazo To defeat Jayson Vayson
BetUS
-1200
Bet Now!

Even without taking those factors into account, it sure looks as though Vayson may be biting off more than he can chew. Collazo is an experienced champion, well-seasoned in bouts facing world-class opposition. Go with Collazo to win in the world strawweight title picks.

Other Notes And Info Regarding Your Boxing Bets

Once you have settled on the wagers you will be making on the boxing betting odds for this world straw weight title bout, you’ll want to be sure to have a look at the massive amounts of data available to you only at OSB. For a more insightful analysis of this bout, be certain to have a look at the boxing betting guide. These guides provide the latest assessments for all of the betting lines that the oddsmakers are setting on the sport. This information will help you assemble some solid boxing picks.

Along those lines, if you’re seeking out the top boxing bets to make, be sure to go ahead and take a look at the best betting sites breakdown, which compiles and distributes quality information, including a complete analysis of what the various sports betting sites are offering to you. Finally, for those who are busy and frequently on the go during the day, the best betting apps rundown is a must-read page to ensure that you place all your boxing bets on time.