Come one, come all, you're just in time to dig into some wildly entertaining betting on the 2022 March Madness tournament. And while most gamblers will tend to gravitate toward 2022 betting odds on the college basketball National Championship, there is a bunch of untapped value to plumb by making early Final Four predictions.
Dropping these 2022 March Madness picks is a matter of identifying the prospective winner from all four brackets: West, East, Midwest and South. Let's start things off by going over the 2022 March Madness odds to win the South Bracket:
| Pick to Win |  |
|---|---|
| Arizona | +140 |
| Tennessee | +340 |
| Houston | +400 |
| Illinois | +800 |
| Michigan | +1600 |
| Ohio State | +2100 |
| Seton Hall | +2400 |
| Loyola Chicago | +2400 |
| TCU | +2900 |
| Colorado State | +3900 |
| UAB | +4900 |
| Chattanooga | +6600 |
| Delaware | +10000 |
| Wright State | +12000 |
| Longwood | +12000 |
| Bryant | +15000 |
Please note all our 2022 March Madness odds are accurate entering Tuesday, March 15. Make sure you're double-checking all of these odds on college basketball prior to settling on any picks, as they will shift throughout the tournament.
Definitely also use this opportunity to check out our reviews of the top online sportsbooks. Many of these sites will be running specials throughout March Madness. For instance, as you can see in our review of the MyBookie sportsbook, they are giving bettors the chance to enter their free MyBracket tournament for a chance to win a hefty share of $100,000 in prizes.
2022 March Madness: Who Will Win the South Bracket?
Both Arizona (+140) and Tennessee (+340) are going to command most of the attention here. But we actually like Houston (+400) to survive this bracket.
Though the Cougars did not get the friendliest pull as a No. 5 seed, they are the most balanced squad in this entire subset. According to KenPom's adjusted performance metrics, Houston profiles as a top-10 team in both offensive efficiency and defensive efficiency. Neither Arizona nor Tennessee comes close to doing the same.
What's more, the Cougars have plenty of guys used to soaking up heavy minutes. Kyle Edwards, Marcus Sasser (currently injured), Jamal Shead and Taze Moore all averaged at least 30 ticks per game during the regular season. Their stamina won't be thrown for a whirl amid a heavier workload.
2022 March Madness: Who Will Win the West Bracket?
Here are the latest odds on which team will win the West bracket of the 2022 March Madness tournament:
| Pick to Win | |
|---|---|
| Gonzaga | -198 |
| Duke | +380 |
| Texas Tech | +550 |
| Arkansas | +1200 |
| Connecticut | +1600 |
| Alabama | +2100 |
| Memphis | +2400 |
| Michigan State | +2900 |
| Boise State | +3400 |
| Rutgers | +3900 |
| Notre Dame | +3900 |
| Davidson | +4900 |
| Vermont | +6600 |
| New Mexico State | +8000 |
| Montana State | +12000 |
| Cal State | +12000 |
| Georgia State | +15000 |
There's no use fighting the odds on this one. Gonzaga (-198) is the monster favorite to come out of the West bracket, and we can't come up with an argument as to why they would not.
Whether they'll win it all is a separate matter. But the field they're facing prior to the Final Four isn't especially harrowing. Duke (+380) is nothing more than a paper tiger given how much their spacing and overall offense has declined. Texas Tech (+550) has similar problems on the offensive end. And next-up candidates like Arkansas (+1200), Connecticut (+1600) and Alabama (+2100) just don't entice us with their defense.
If you have the ability to stomach a bunch of risk, keep your eye on Memphis (+2400). This is not the same team that struggled to start the year. They have ranked among the most effective teams in the nation at both ends of the floor over the past couple of months. So while they're enterting as a nine-seed, they're more like a three- or four-seed in our book.
2022 March Madness: Who Will Win the Midwest Bracket?
Here are the latest odds on which team will win the Midwest bracket of the 2022 March Madness tournament:
| Pick to Win | |
|---|---|
| Kansas | +160 |
| Auburn | +224 |
| Iowa | +350 |
| Wisconsin | +900 |
| LSU | +1200 |
| San Diego State | +1400 |
| Providence | +1400 |
| USC | +1900 |
| Miami-Florida | +1900 |
| Iowa State | +1900 |
| Creighton | +2400 |
| Richmond | +4900 |
| South Dakota State | +6400 |
| Colgate | +8000 |
| Texas A&M | +12000 |
| Texas Southern | +12000 |
| Jacksonville State | +12000 |
Most will be thinking about Kansas (+160) or Auburn (+224) in this spot. We get it. They are flashier teams and more successful programs.
But San Diego State (+1400) is piquing our interest more than any other team.
Indeed, they haven't been the most consistent offensive squad. They don't get to the free-throw line a ton, and they're overly reliant on Matt Bradley's shot-making to get them by. Still, San Diego's defense is hellacious. They rank second in the nation in points allowed per 100 possessions when adjusting for strength of schedule.
History tells us elite defensive teams that hit a good amount of their threes can advance deep into the March Madness tournament. And as a defensive juggernaut nailing nearly 36 percent of their triples, San Diego State absolutely meets this criteria.
2022 March Madness: Who Will Win the East Bracket?
Here are the latest odds on which team will win the East bracket of the 2022 March Madness tournament:
| Pick to Win | |
|---|---|
| Kentucky | +150 |
| Baylor | +250 |
| Purdue | +300 |
| UCLA | +350 |
| Texas | +1000 |
| Virginia Tech | +1600 |
| Saint Mary's | +1900 |
| North Carolina | +1900 |
| San Francisco | +2900 |
| Murray State | +2900 |
| Indiana | +3400 |
| Marquette | +3900 |
| Wyoming | +8000 |
| Yale | +8000 |
| Saint Peters | +10000 |
| Norfolk State | +15000 |
| Akron Wayne | +100000 |
The East may have the toughest bracket to figure out. Kentucky (+150) enters as the deserved favorite, but we're not quite sure if we trust their outside shooting. Baylor (+250) is both the defending champion and wielding a top-15 offense and defense. Purdue (+300) might just have the best offense in the country.
People need to give UCLA (+350) more credit, too. They play a feisty brand of defense while also executing at an otherworldly level on the offensive side.
When push comes to shove, we lean Baylor. They always seem a couple of made threes away from world domination.
Take a look at this list of the top online sportsbooks so you can decide which one to use for all of your 2022 March Madness betting:
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