Ole Miss vs Tulane Picks

What: #11 Tulane Green Wave at #6 Ole Miss Rebels
Where: Vaught-Hemingway Stadium in University, MI
When: Saturday, December 20th at 3:30pm EST

Ole Miss (11-1) will host Tulane (11-2) in the first round of the College Football Playoff. The Rebels destroyed the Green Wave 45-10 back on September 20th but have undergone some turmoil in the past month after Lane Kiffin's messy exit to LSU.

Let's look at the latest betting lines with the winner set to advance to face No. 3 Georgia in the Sugar Bowl on New Year's Day. Odds are subject to change.

	Spread	Money Line	Total Points
Tulane	+17.5 (-115)	+550	Ov 56.5 (-110)
Ole Miss	-17.5 (-105)	-850	Un 56.5 (-110)

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Rebels vs Green Wave

Ole Miss is a massive 17.5-point home favorite on Saturday. The Rebels were actually 23.5-point favorites going into their September game, suggesting that oddsmakers believe former head coach Lane Kiffin will be missed to some degree. Kiffin, of course, left Oxford for LSU after winning 55 games in six seasons.

The OVER/UNDER is set at 56.5 points with offensive coordinator Charlie Weis Jr. still in charge of Kiffin's high-scoring versatile attack. The Rebels should put up plenty of points against a Green Wave defense that ranked 121st against the pass and 101st versus the run. Tulane allowed 548 total yards to Ole Miss in their first matchup.

This man leads Ole Miss out of the tunnel Saturday afternoon

Playoff football in Oxford, MS pic.twitter.com/8wepFlCMSc

— Everything Ole Miss (@EverythingRebs) December 15, 2025

Quarterback battle

Trinidad Chambliss passed for 3,016 yards with an 18-3 touchdown-to-interception ratio after unseating opening day starter Austin Simmons. The explosive senior QB also added 523 rushing yards and 6 TDs on the ground. Chambliss is poised for a big performance against a Tulane defense surrendering 255.2 passing yards per game with a 139.02 QB rating.

Jake Retzlaff completed only five of 17 passes for 56 scoreless yards in a 45-10 loss to Ole Miss in September. New Rebels coach Pete Golding ran Kiffin's defense in that game. He'll be aggressive against Retzlaff, who has a 0-4 TD-INT ratio when pressured.

Tulane's coach still in place

Tulane's coach Jon Sumrall is leaving for Florida, but unlike Kiffin, he's sticking around for the CFP Playoff. Despite his presence, this looks like a mismatch on paper.

Ole Miss dominated on the ground in their first meeting, compiling 241 yards with a 5.7 yards-per-carry average. With a dual-threat QB in Chambliss and a talented RB in Kewan Lacy, it's hard to see how the Green Wave will shut the Rebels down.

Jon Sumrall, who will leave Tulane for Florida after this season, has donated $100,000 to support his former program and the Green Wave's new head coach.

The donation will "directly strengthen Tulane's ability to recruit, retain" football talent. pic.twitter.com/Vzl8aUB3eX

— Front Office Sports (@FOS) December 15, 2025

Ole Miss will almost certainly advance in the CFP Playoff to face Georgia in the Sugar Bowl. While Kiffin's loss could prove to be a distraction, a motivated Rebels team should cover the points (-17.5) versus Tulane, with the UNDER 56.5.

Ole Miss to cover vs Tulane