Liverpool vs Real Madrid UEFA Champions Leage Picks / OSB

What: UEFA Champions League Matchday 4
Who: Liverpool vs Real Madrid
When: Tuesday, November 4, 2025
Where: Anfield
Watch: Paramount+/TUDN, 3:00 pm ET

The clubs with the most overall titles in the competition are going head-to-head in Matchday 4 of the UEFA Champions League competition. Real Madrid, Spanish La Liga leaders, are away to reigning English Premier League champions Liverpool.

Oddsmakers are setting the home side as slight +147 favorites. You will get a +158 underdog betting line if you opt to go with Real Madrid in the soccer odds.

Let’s look at the latest soccer betting lines for this match. Remember, the odds are always subject to change.

UEFA Champions League Matchday 4 Odds	The Pick
Liverpool vs Real Madrid	Draw	+285	+285	+292

In this article, OSB will review the match, predict the winner of the matchup, and provide additional notes and information on soccer picks and betting.

Best UEFA Champions League Betting Tips

Keep on top of the latest betting updates on UCL action by checking in with our UEFA Champions League page. If you're new to wagering on soccer, our soccer betting page is chock full of the best wagering advice and handy betting tips.

The UEFA Champions League is a months-long competition, but thanks to your mobile device, you'll never be more than moments away from placing your UCL wagers. Take advantage of the top mobile betting apps to place a bet wherever you might be in the course of your day.

Match Overview: Liverpool vs Real Madrid

Real Madrid has won a record 15 UCL titles. They won the first title in 1956. Real Madrid's most recent win came in 2024. The Spanish side beat Liverpool in the 2018 and 2022 finals.

Liverpool has been the UEFA Champions League winner six times. The most recent triumph for the Reds came in 2019.

Team Spotlight: Liverpool

It's been a rough go for the perennial EPL contenders so far this season. Liverpool ended a stretch of six losses in seven matches in all competitions with a 2-0 EPL victory over Aston Villa on Saturday.

Wirtz footwork and pass 🤤#UCL pic.twitter.com/nfp3RIsnak

— UEFA Champions League (@ChampionsLeague) October 28, 2025

The only win in the previous seven matches was a resounding 5-1 rout of Eintracht Frankfurt on UCL Matchday 3. Liverpool currently sits 10th in the UEFA Group table with two wins and a loss.

Team Spotlight: Real Madrid

Since being dumped 5-2 by Atletico Madrid on September 27, Real Madrid has caught fire. The Spanish side has won six successive matches in all competitions.

The holders are 🔝 after MD3#UCL pic.twitter.com/ykHaXQnryL

— UEFA Champions League (@ChampionsLeague) October 22, 2025

During that span, Real Madrid has outscored the opposition 16-2. The club has kept four clean sheets in that span and never allowed more than one goal in any match.

Real Madrid is 3-0 in UCL Group Stage matches, but is fifth in the table on goal differential.

Best Liverpool vs Real Madrid Prop Bets

If you want to bet on this match ending as a draw, the odds on that play in the UCL soccer prop bets are +285. Oddsmakers are setting the spread on the match as a pick'em. You'll get -115 odds if you wager on Liverpool. Back a spread bet with Real Madrid at a soccer betting line of -105.

The total for the match is 3.5 goals. Bet the over at -120, or go with the under, and the action is set at even money. Five of Real Madrid's last eight matches have gone over this total. However, eight of Liverpool's past 10 matches finished under this total.

Other soccer props feature odds of -270 on yes and +200 on no in a both teams to score play. Liverpool to win by one goal is the +370 favorite in a margin of victory prop bet. The Reds are set with odds of +390 to post a clean sheet. You'll get +410 odds on the same prop if you go with Real Madrid.

In the UCL player props. Real Madrid's Kylian Mbappe is the +375 chalk to net the first goal of the match. Liverpool's Alexander Isak is set with soccer odds of +120 to be an anytime scorer during the match.

Latest UEFA Champions League Futures

The record 15-time champs Real Madrid are given a betting line of +900 to win the UEFA Champions League in soccer futures betting. Liverpool is set with a line of +700 in the soccer odds to win the UCL.

The defending champions from PSG are set as the +450 betting choice to win the 2025-26 UEFA Champions League title. Current English Premier League leaders Arsenal are next in this betting market at odds of +500.

Spanish side Barcelona, a five-time UCL winner, is given odds of +600 to be the winner of this season's title. Six-time winners Bayern Munich are at +900, while the 2023 UCL champions Manchester City are offering soccer betting odds of +900.

Best Bet To Win On UEFA Champions League Matchday 4

Liverpool beat Real Madrid 2-0 in Group Stage play last year. That result ended a four-match losing streak against the Spanish side in UCL play.

Liverpool vs Real Madrid To play to a draw on UCL Matchday 4

+285

Bet Now!

The meeting before that ended in a scoreless draw, and that seems like a realistic possibility here, as Liverpool still seeks to find some stable footing this season. Bet on a draw between Liverpool and Real Madrid in the UEFA Champions League Matchday 4 picks.