• What: UFC Fight Night
  • Who: Sean Strickland vs Anthony Hernandez, middleweight bout; Juliana Miller vs Carli Judice, women's flyweight bout
  • Where: Toyota Center, Houston, Texas
  • When: Saturday, February 21, 5:00 p.m. EDT
  • Watch: Paramount+

Two former middleweight champions will be headlining the main event at UFC Fight Night on Saturday, February 21, in Houston, Texas.

Former UFC world champion Sean Strickland will be squaring off against Anthony Hernandez, once the LFA champion, in a showdown of top middleweight contenders

Oddsmakers are setting Hernandez as the solid -280 favorite in the UFC betting lines.

Let's look at the latest betting lines. Odds are subject to change.

UFC Fight Night OddsThe PickMyBookieBetOnlineBetUS
Sean Strickland vs Anthony HernandezHernandez-295-270-280
Juliana Miller vs Carli JudiceJudice-750-750-750

The co-main event is a women's flyweight bout between The Ultimate Fighter: Team Peña vs. Team Nunes flyweight winner Juliana Miller and Carli Judice. The UFC betting lines are showing Judice as the massive -750 chalk to take this bout.

In this article, OSB will be analyzing the fighters in each of these main-event bouts. A predicted winner in both matchups will be offered. There will also be some additional notes and information regarding the UFC Fight Night picks. UFC betting tips will also be provided.

UFC Fight Night Overview: Sean Strickland vs Anthony Hernandez

A title shot could be awaiting the winner of this bout. Strickland is currently the No. 3 contender in the UFC middleweight division. Hernandez is right behind him, rated as the No. 4 contender in the weight class.

Fighter Spotlight: Sean Strickland

The experienced Strickland (29-7) reigned as UFC middleweight champion from 2023-24. He won the title in a stunning upset of Israel Adesanya. However, Dricus du Plessis took the title belt from Strickland in his first defense via split decision. Before signing with UFC, Strickland was King of the Cage champion, going 9-0 in that promotion.

In a 2025 rematch for the title against du Plessis, the 34-year-old Strickland lost again, this time by unanimous decision. He's a middling 4-4 over his past eight fights. Strickland owns the mark for the most significant strikes landed in UFC middleweight division history at 1465.

Fighter Spotlight: Anthony Hernandez

Hernandez (15-2) lost two of his first three fights after joining UFC. However, he comes into this bout riding an eight-fight win streak. Hernandez, 32, hasn't tasted defeat since 2020. Four of those wins were earned via submission and two by knockout.

He's won Performance of the Night in three of his past four fights. Hernandez's 62.8% striking accuracy percentage is the second-best in UFC middleweight division history.

Prediction: Both Strickland and Hernandez own well-deserved reputations as punishing strikers. The difference is that Strickland looks to finish off opponents with his striking prowess, while Hernandez utilizes his punching power to set up his opponents for a takedown.

Anthony Hernandez To defeat Sean Strickland
BetUS
-280
Bet Now!

Once he takes another fighter to the mat, Hernandez gets to display his masterful grappling skills to overwhelm them. His ability to gain submission holds has led to an 80% finishing rate for Hernandez in his fights. He'll take Strickland down, and then he'll force him to submit. Bet on Hernandez to win this bout in the UFC picks.

UFC Fight Night Overview: Juliana Miller vs Carli Judice

This fight was originally to have taken place on a UFC Fight Night card a year ago. However, an injury suffered by Miller led to a postponement of the bout.
Fighter Spotlight: Juliana Miller
Miller (5-3) defeated Brogan Walker via a third-round knockout to earn the Ultimate Fighter women's title in 2022. The 29-year-old American has lost two of her three bouts since that victory.

Miller comes into this fight off a unanimous decision victory over Ivana Petrovic.
Fighter Spotlight: Carli Judice
American Judice (5-2) has won her past two fights by knockout. In fact, she's captured all five of her career victories by KO or TKO. Her latest win streak followed on the heels of a two-match losing skid, in which Judice lost both fights via decision.

Once a softball player, Judice has only been involved in MMA for five years. However, she was named among the 2026 fighters to watch in the UFC promotion.

Prediction: This fight pits one of the hottest prospects in the division against a made-for-TV competitor. That would explain why oddsmakers are leaning heavily toward Judice in the UFC betting odds.

Carli Judice To defeat Juliana Miller
BetOnline
-750
Bet Now!

Miller's nickname is Killer, but it's Judice who's been delivering the killer performances in the octagon. She put out Yuneisy Duben's lights with a punishing head kick. Judice assembled a combination body shot/ground and pound to overcome Nicolle Caliari. It will be tempting to take the massive price on Miller. Don't go there. Go with Judice to win in the UFC picks.

Boost Your UFC Picks

Before getting your wagers down on UFC Fight Night, don't forget to check out the best UFC betting odds to ensure you are getting the best bets available. You can also use sportsbook reviews 2026 to find a betting site to service your needs in UFC betting picks. And if you're new to the world of online sports betting, don't fret about being in over your head. There are plenty of how-to tips that you can peruse in our handy sports betting guide.