• What:  San Marino Grand Prix MotoGP Picks
  • Where: Misano World Circuit Marco Simoncelli
  • When: September 13, 2025
  • Watch: FOX Sports, 8 am EST

As the MotoGP riders move on to Round 16 of the series at the San Marino Grand Prix, the Marc Marquez win streak has come to an end. However, the winning ways of the Marquez family continue unfettered.

In the Catalan Grand Prix, for the first time since May, series leader Marc Marquez saw the back of another rider at the finish line. It was that of his younger brother Alex Marquez.

The Spanish rider for the Ducati Lenovo factory team had won the previous seven races of the 2025 season. With nine wins on the year, Marc Marquez has extended his series lead to 182 points.

The elder Marquez is the overwhelming favorite to resume winning, starting with this race. Oddsmakers are setting the series leader as the -225 odds-on favorite to return to victory lane in San Marino.

Let’s look at the latest San Marino Grand Prix MotoGP betting lines. Remember, odds are always subject to change.

MotoGP San Marino Grand Prix OddsBovadaBetOnlineBetUS
Marc Marquez-225-220-225
Alex Marquez+400+400+400
Francesco Bagnaia+1100+1000+1100
Marco Bezzecchi+1100+1200+1100
Enea Bastianini+1800+2000+1800
Fabio Quartararo+1800+1600+1800
Pedro Acosta+2200+2200+2200
Fabio Di Giannantonio+2800+2900+2800
Franco Morbidelli+4000+4000+4000
Brad Binder+5000+5000+5000
Fermin Aldeguer+6000+6000+6000
Johann Zarco+6000+5000+6000
Jorge Martin+6000+6000+6000

Marc’s younger brother is the second betting choice at +400. Two-time world champion Francesco Bagnaia and Marco Bezzecchi are next, each with MotoGP betting lines of +1100. Enea Bastianini (+1800) and Pedro Quartararo (+1800) are the only other riders with odds shorter than +2200.

Marc Marquez Leading MotoGP Series

Marc Marquez is the defending champion in the San Marino Grand Prix. However, the race has seen four different winners over the past five races.

In this season’s race, following Saturday qualifying will be the 13-lap sprint. The 27-lap main event race is set for Sunday at 8 a.m. EST around the 16-turn, 2.63-mile Misano World Circuit Marco Simoncelli layout. Remember, the race odds could be changing based on the results of the qualifying round and the sprint race. That’s why it’s always wise to track the early outcomes. You’ll be able to see which riders are holding hot hands and are the best for you to bet.

Let's look at the top contenders for this race.

Marc Marquez (-225)

Not only did Marquez win this race last year, but he's also won the San Marino Grand Prix more than any MotoGP rider.

He's won on this circuit seven times, including four MotoGP triumphs. Marquez won the San Marino Grand Prix in MotoGP in 2015, 2017, and 2019, as well as in 2024.

Alex Marquez (+400)

The younger Marquez was dominant in all facets of the race while winning the Catalan Grand Prix.

Along with his race victory, the Spaniard also won pole position and turned the fastest lap in the race.

Francesco Bagnaia (+1100)

Bagnaia's name is all over the record book for the Misano World Circuit Marco Simoncelli. The Italian rider's resume displays that his name is etched to the most poles won (four), fastest qualifying time (1:30.031) all-time fastest lap (1:30.031), and fastest race lap (1:30.877).

Each of the latter three marks was achieved during last year's race. Bagnaia won the San Marino Grand Prix in 2021 and 2022.

Marco Bezzecchi (+1200)

Bezzecchi owns the fastest speed ever recorded on this circuit. His bike reached 190.077 mph during the 2023 race.

Enea Bastianini (+1800)

Italy's Bastianini has finished on the podium in all three of his MotoGP starts in the San Marino Grand Prix. He was third here last year and in 2021. Bastianini finished second in 2022.

Fabio Quartararo (+1800)

If only Quartararo could finish like he starts. He's earned four poles this season.

That's led to a solitary podium finish. Quartararo was second in the Spanish Grand Prix.

Latest MotoGP Championship Odds

In MotoGP futures, the latest betting lines on the world championship list Marc Marquez as a massive -25000 favorite to win his seventh career world title and first since 2019. In his last 10 races, Marquez has shown seven wins, two seconds, and a third.

Alex Marquez is a distant second betting choice at +4000. Then you go all the way back to two-time champion Bagnaia with odds of +40000.

San Marino Grand Prix MotoGP Best Bet

The previous time Marc Marquez lost to his brother this season, he also lost the next two MotoGP races. But he won here last year. And Ducati riders have won the past four San Marino Grand Prix races.

Marc Marquez To win MotoGP San Marino Grand Prix
BetUS
-220
Bet Now!

The sensational Spanish rider had won seven races in a row before his second-place at Catalan. Historically, no rider has proven more dominant on this circuit than Marc Marquez. Go with him to win in the MotoGP San Marino Grand Prix picks.

Additional Thoughts And Notes Regarding MotoGP Bets

Once you are all up to speed on the latest MotoGP San Marino Grand Prix news and information, make sure to check out the fantastic array of resources for you over at OSB. Of course, for even more analysis on the topic covered here, you should bookmark the MotoGP betting sites rundown. On this page, you can find a variety of awesome information as it relates to the sport, including the latest betting markets and beyond. Additionally, for those on the go, another fantastic page to familiarize yourself with is the best betting apps breakdown, which goes over all of the nuances of mobile betting sites and beyond. Finally, for those interested in maximizing their wagers, look no further than the best betting sites guide, which contains an extensive compilation of tips and how-to suggestions.