Broncos vs Jaguars Picks | 12-21-25 | Online Sports Betting

What: Jacksonville Jaguars at Denver Broncos
Where: Empower Field at Mile High
When: 4:05 PM EST, Sunday, December 21st, 2025

Denver hosts Jacksonville on Sunday in a matchup of the NFL's two hottest teams. With 11-consecutive wins, Sean Payton's Broncos are currently holding down the No. 1 seed in the AFC and a first-round bye. Meanwhile, Liam Coen's Jaguars are looking for their sixth victory in a row after demolishing the New York Jets on Sunday.

Let's look at the latest betting lines for Broncos vs Jaguars in Week 16. Odds are subject to change.

	Spread	Money Line	Total Points
Jacksonville Jaguars	+3.0 (-105)	+140	Ov 46.0 (-105)
Denver Broncos	-3.0 (-115)	-175	Un 46.0 (-115)

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Broncos favored at Mile High

Denver is a 3-point home favorite over Jacksonville at Mile High Stadium this Sunday with the OVER/UNDER set at 46 points. Bo Nix is coming off a career-best performance, passing for 302 yards and four touchdowns in a 34-26 win over the Packers. The sophomore QB wasn't sacked once on 34 dropbacks while connecting with Courtland Sutton (113 yards, TD) and Troy Franklin (85 yards, TD) for chunk plays.

After allowing Green Bay to score on their first five drives, the Broncos defense took over the game in the second half, picking off Jordan Love twice.

Bo Nix joined HOF QB Dan Marino as the only quarterbacks in NFL history with at least 20 wins, 7,000 pass yards and 50 pass touchdowns in their first two career seasons

The milestones keeping coming for 🔟#BroncosCountry pic.twitter.com/J6GcHpuXgF

— SleeperBroncos (@SleeperBroncos) December 15, 2025

Trevor Lawrence's career resurgence

Trevor Lawrence threw for 330 yards and a career-high five touchdowns in a 48-20 victory over the Jets in Week 15 while adding 51 yards and a score on the ground. After a wildly disappointing start to his career, the former No. 1 overall pick is flourishing under first-year head coach Liam Coen.

In his past four games, Lawrence has passed for 12 TDs with just 3 interceptions. However, it's fair to point out those numbers were compiled against four non-playoff teams in the Cardinals, Titans, Colts and Jets.

Recent matchups

At 10-4, Jacksonville is in the driver's seat in the AFC South and poised to host a postseason game on Wild Card Weekend. While the Jaguars have defeated playoff teams like the Chargers, 49ers and Texans, a victory in Mile High would be momentous.

The 12-2 Broncos haven't lost since September. They're 7-0 at home and have 10 one-score wins this season.

Trevor Lawrence is the only player in NFL history with 5+ Pass TDs, 1+ Rush TD and 50+ Rush Yds in a single game 😤 pic.twitter.com/k7vyNLso93

— NFL on Prime Video (@NFLonPrime) December 15, 2025

Denver Broncos vs Jacksonville Jaguars Picks

With Trevor Lawrence finally looking like a franchise quarterback, Shahid Khan and the Jaguars have to be ecstatic about stealing Liam Coen away from the Buccaneers. But, Jacksonville is still being overvalued here. Take the Broncos to cover at home (-3) with the UNDER 46.

Denver Broncos to cover vs Jaguars