Broncos vs Bills Picks | 01-17-26 | Online Sports Betting

What: Buffalo Bills at Denver Broncos
Where: Mile High Stadium
When: 4:30 PM EST, Saturday, January 17, 2025

After ending the second-longest road playoff losing streak in NFL history at eight games, Josh Allen and the Bills will have to win another away contest on Saturday to reach its second-straight AFC Championship Game.

Coming off a first-round bye, Denver put together an 8-1 record at Mile High Stadium this season. Let's look at the latest betting lines for Broncos vs Bills. Odds are subject to change.

	Spread	Money Line	Total Points
Buffalo Bills	+1.0 (-115)	-120	Ov 46.5 (-115)
Denver Broncos	-1.0 (-105)	-110	Un 46.5 (-105)

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Broncos open as slight favorites

Denver is a 1-point home favorite at Mile High Stadium on Saturday, with the over/under set at 46.5 points. The Broncos only lost three games all season. However, their only home defeat came in Week 16 to the Jaguars - the same team that Buffalo defeated to reach the Divisional Round.

Despite being battered and bruised all game, Josh Allen passed for 273 yards and a touchdown in a 27-24 victory over Jacksonville, adding 33 yards and two scores on the ground.

There are real-life humans who will go on TV and tell you Josh Allen hasn't been good in the playoffs. pic.twitter.com/YxXURhZlKk

— Greg Vorse (@GregVorse) January 11, 2026

Can Allen solve Denver's D?

Josh Allen was almost perfect on Sunday, connecting on 28 of 35 passes (80%) with 7.8 yards per attempt, a 108.7 passer rating and three total TDs. He was also unshakable in big moments, finishing 9 for 12 for 144 yards under pressure to deliver Buffalo's first road playoff win since 1992.

Standing in the way of Allen reaching a third-career AFC Championship Game is a Broncos defense that ranked fourth in points allowed per game (18.3), second in rushing yards allowed per game (91.1) and seventh in passing yards allowed per game (187.2).

Playoff rematch

Josh Allen and the Bills ran away with a 31-7 victory over Denver in last year's wild-card round. Allen finished with 272 passing yards and 2 TDs, and James Cook ran for 120 yards and a score. Bo Nix passed for just 144 yards and a TD in the loss.

The sophomore QB has played well since the Broncos' Week 12 bye with low interception (1.2%) and sack (4.0%) rates. However, he may have trouble attacking through the air on Buffalo's second-ranked pass defense, which allows only 159.6 yards per game.

Bo Nix's lone playoff game was against the Bills in the Wild Card last season...

He gets Josh Allen and the Bills again in the Divisional 🍿 pic.twitter.com/SSKhx1KO1V

— Bleacher Report (@BleacherReport) January 12, 2026

Denver Broncos vs Buffalo Bills Picks

After many analysts picked against Buffalo last week, expect many to jump back aboard the Josh Allen bandwagon leading up to Saturday's game. With Patrick Mahomes, Lamar Jackson and Joe Burrow all missing from the postseason, this could be the last chance for the dual-threat superstar to drag the Bills to the Super Bowl.

Take Buffalo to win (-120) at Mile High with the UNDER 46.5 points.

Buffalo Bills to win vs Broncos

-120

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