Patriots vs Bills Picks | 12-14-25 | Online Sports Betting

What: Buffalo Bills at New England Patriots
Where: Gillette Stadium in Foxborough, MA
When: 1 PM EST, Sunday, December 14th, 2025

Drake Maye and the Patriots will host Josh Allen and the Bills on Sunday. Coming off a bye with a 11-2 record, New England can clinch their first division title since 2019 and end Buffalo's five-year reign atop the AFC East.

Let's look at the latest betting lines for Sunday's pivotal game. Odds are subject to change.

	Spread	Money Line	Total Points
Buffalo Bills	-1.0 (-105)	-115	Ov 49.5 (-110)
New England Patriots	+1.0 (-115)	-105	Un 49.5 (-110)

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Buffalo opens as slight road favorite

Buffalo is a 1-point road favorite at Gillette Stadium on Sunday. Josh Allen is coming off a masterful performance in a 39-24 victory over the Bengals in which he passed for 251 yards and three touchdowns.

Sean McDermott's club trailed Cincinnati 28-18 in the fourth quarter before the 29-year-old quarterback busted off a franchise-record 40-yard TD run. On the next possession, Christian Benford returned a Joe Burrow interception 63 yards for a score. And on the very next play, the Bills picked off Burrow again to seal the victory.

Josh Allen becomes the first player in NFL history to have 1+ pass TD and 1+ rush TD in 50 games 🫡

📲 Stream with NFL+pic.twitter.com/cuDE2Y8MAD

— NFL+ (@NFLPlus) December 7, 2025

Patriots coming off a bye week

The OVER/UNDER for Sunday's contest is 49.5 points. Both teams have top 10 scoring offenses with Buffalo (28.9 PPG) just ahead of New England (27.0). The Patriots are also top five in scoring defense, however, permitting just 18.5 PPG. The Bills (22.5 PPG allowed) rank 14th in the league.

Before enjoying a Week 14 bye, Drake Maye passed for 282 yards, two touchdowns and no interceptions in a 33-15 beatdown of the Giants. At +210 to win 2025 NFL MVP, the sophomore quarterback trails only Rams pivot Matthew Stafford (-170) in the awards markets.

Recent history

New England defeated their AFC East-rivals 23-20 back in Week 5, snapping a 14-game home winning streak and handing the Bills their first loss of the season. Stefon Diggs excelled against his former club, hauling in 10 receptions for 146 yards.

Mike Vrabel's defense held dynamic running back James Cook to just 49 yards on 15 carries, and Buffalo accepted penalties for 90 yards against them. Maye passed for 273 yards with no touchdowns or interceptions. Allen threw for 253 yards, 2 TDs and an INT while running for 53 yards.