Mahomes and Chiefs to bury Josh Allen's Bills in Buffalo on Sunday

What: Kansas City Chiefs at Buffalo Bills
Where: Highmark Stadium in Orchard Park, NY
When: 4:25 PM EST, Sunday, November 2nd, 2025

Josh Allen and Patrick Mahomes will square off for the 10th time in their careers on Sunday. While the Chiefs quarterback is undefeated against his rival in the playoffs, Allen is 4-1 against Mahomes in the regular season.

Who will win win the Week 9 showdown? Let's look at the latest betting lines for Bills vs Chiefs. Odds are subject to change.

	Spread	Money Line	Total Points
Kansas City Chiefs	-2.0 (-110)	-130	Ov 52.5 (-115)
Buffalo Bills	+2.0 (-110)	+110	Un 52.5 (-105)

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Chiefs favored in Orchard Park

Kansas City is a 2-point road favorite on Sunday thanks to the play of Patrick Mahomes. Currently favored to win his third-career NFL MVP award, the 30-year-old superstar is tied with Matthew Stafford for the league lead in touchdown passes (17) after throwing three in three consecutive games.

The OVER/UNDER of 52.5 points is the 2nd highest of the Week 9 slate. Coming off a 40-9 post-bye beat down of the Panthers, Buffalo is the fourth-highest scoring team (29.6 PPG) in the NFL while the Chiefs rank seventh (26.8 PPG) and come into the contest riding a three-game winning streak.

Patrick Mahomes joins HOF Peyton Manning as the only players ever with 40,000+ pass yards in their first 9 seasons, including playoffs 💪#ChiefsKingdom pic.twitter.com/kahbEz5AYV

— NFL+ (@NFLPlus) October 28, 2025

Can Buffalo get their run game rolling?

James Cook ran for 216 yards and 2 TDs in last Sunday's win versus Carolina. With 753 rushing yards this season, he trails only Jonathan Taylor (850) and is a big reason why the Bills average the highest time of possession in the league. However, Cook will be up against a Kansas City defense that's allowing the second-fewest points per game (16.4) in the NFL.

Ed Oliver's injury looms large

The Chiefs are one of only two teams without a 100-yard rusher or 100-yard receiver this season. But they have the best total offense in the NFL since Week 4, averaging 415.8 yards per game.

Buffalo will need to pressure Mahomes to take him out of rhythm. While they'll be without standout defensive tackle Ed Oliver, who was put on IR with a biceps injury, the Bills defensive line swarmed the Panthers in Week 8 for seven sacks and three takeaways.

"Looking at Josh [Allen], the one word I would use to describe him is frustrated."@danorlovsky7 and @Hawk analyze how the Bills' offensive core can help Josh Allen ✍️ pic.twitter.com/AnNEzfZPaX

— NFL on ESPN (@ESPNNFL) October 29, 2025

Buffalo Bills vs Kansas City Chiefs Picks

Since their season-opening comeback victory over the 2-5 Ravens, Sean McDermott's squad has defeated a murderer's row of tomato cans (Jets, Dolphins, Saints, Panthers) while losing in prime-time to both the Patriots and Falcons.

Meanwhile, the Chiefs are red-hot since the return of receivers Xavier Worthy and Rashee Rice. With Travis Kelce on pace for his first 1,000-yard season since 2022, Andy Reid has too many weapons at his disposal to be stopped.

Take Kansas City to cover (-2) on the road with the OVER 52.5.

Kansas City to cover vs Bills