Ravens vs Patriots Picks | 12-21-25 | Online Sports Betting

What: New England Patriots at Baltimore Ravens
Where: M&T Bank Stadium
When: 8:20 PM EST, Sunday, December 21st, 2025

Drake Maye and the Patriots blew a 17-point halftime lead to the division-rival Bills in Week 15, ending their win streak at 10. Still one game ahead of Buffalo in the AFC East, New England will try to bounce back against a Baltimore team fighting for their playoff lives.

Let's look at the latest betting lines for Ravens vs Patriots in Week 16. Odds are subject to change.

	Spread	Money Line	Total Points
New England Patriots	+3.0 (-110)	+145	Ov 48.0 (-115)
Baltimore Ravens	-3.0 (-110)	-170	Un 48.0 (-105)

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Ravens favored at home

Baltimore is a 3-point favorite at M&T Bank Stadium after ending a two-game slide with a 24-0 victory over the Bengals in Week 15. While Lamar Jackson only passed for 150 yards, he tossed multiple TD passes for the first time in six games. John Harbaugh's defense intercepted Joe Burrow twice in the shutout, including a 95-yard pick-six by Kyle Van Noy and Alohi Gilman.

Sunday night's contest has a 48-point OVER/UNDER. Sitting one game back of the Steelers in the AFC North with three games (NE, @GB, PIT) to play, the Ravens are in must-win territory.

Always the consummate gentleman, Lamar Jackson shared his coat during our postgame chat. Thank you, @Lj_era8, for taking pity on a sideline reporter-slash-icicle. 😂 pic.twitter.com/z6bpJeXPrT

— Aditi Kinkhabwala (@AKinkhabwala) December 15, 2025

Patriots collapse

New England scored three touchdowns in their first four possessions to take a 21-0 lead over the Bills. However, Mike Vrabel's defense couldn't contain Josh Allen, allowing Buffalo TDs on its first five red zone drives. Drake Maye was also bottled up in the second half, passing for just 47 yards.

Despite falling to 11-3, the Patriots are still in the driver's seat to win their first AFC East title since 2019. But their grip on the division would loosen with a loss to Baltimore.

Key matchups

Derrick Henry rushed for 100 yards on only 11 carries versus the Bengals, busting off three runs of 22 yards and longer after halftime. King Henry now faces off against former coach Mike Vrabel. While he presides over a top-five run defense allowing only 95.1 yards per game, James Cook torched the Patriots for 107 yards and 2 TDs in Sunday's loss.

The Ravens shutout Joe Burrow in Week 15, but they have the 7th-worst pass defense in the NFL, allowing 233.3 yards per game.

I'm sure it has happened before and often, but I can't get enough of back Drake Maye, OUR QB, running step for step with TreVeyon Henderson on his TD run.

He was winded. 😅😮‍💨

🎥: @Patriots pic.twitter.com/P9ESjBuWuc

— Michael Rodnick (@MJRodnick) December 17, 2025

Baltimore Ravens vs New England Patriots Picks

It's important to remember that New England has been a good team all year and is coming off a close loss to a real-life superhero in Josh Allen. Meanwhile, the Ravens have been mediocre all season and just beat up on a 4-10 Bengals team.

Take the Patriots to cover the points (+3) and win outright (+145) versus Baltimore with the UNDER 48.

New England to win vs Ravens