Rams vs Lions Picks | 12-14-25 | Online Sports Betting

What: Detroit Lions at Los Angeles Rams
Where: SoFi Stadium in Inglewood, CA
When: 4:25 PM EST, Sunday, December 14th, 2025

Matthew Stafford will host Jared Goff in a double revenge game on Sunday afternoon with both quarterbacks looking to topple their former teams. Coming off a season-saving win over the Cowboys last Thursday night, Detroit needs a win over Los Angeles to keep pace in the NFC playoff hunt.

Let's look at the latest betting lines for Rams vs Lions in Week 15. Odds are subject to change.

	Spread	Money Line	Total Points
Detroit Lions	+5.0 (-110)	+210	Ov 54.0 (-110)
Los Angeles Rams	-5.0 (-110)	-250	Un 54.0 (-110)

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Rams favored at home

Los Angeles is a 5-point home favorite at SoFi Stadium this Sunday. The NFC West-leading Rams rebounded from a surprising loss to the Carolina Panthers to demolish the Arizona Cardinals on Sunday. Matthew Stafford passed for 281 yards, three touchdowns and no interceptions in a 45-17 win. Closing in on his first-career NFL MVP award, the 37-year-old quarterback has thrown multiple TDs in seven straight games.

Puka Nacua was unstoppable as ever, hauling in seven receptions for 167 yards and two scores. Kyren Williams and Blake Corum combined for 212 rushing yards and three TDs on 25 carries.

Moving up the leaderboard. 📋

Matthew Stafford | #ProBowlVote pic.twitter.com/Ac8Hwh9i8U

— Los Angeles Rams (@RamsNFL) December 7, 2025

Gibbs powers Lions offense

With two of the NFL's highest-scoring offenses going head-to-head in a dome, the 54-points OVER/UNDER is the highest on the Week 15 slate. Pacing the league in points per game (30.3), Detroit is coming off a 44-30 victory over the Cowboys last Thursday.

Jahmyr Gibbs ran for three touchdowns while making seven grabs for 77 yards in the win, and Jameson Williams put up a team-high 96 receiving yards. Amon-Ra St. Brown also put forward a gutsy effort on a hobbled ankle with six receptions for 92 yards.

Recent matchups

These two NFC powers have played each other tight in recent years. Detroit ended a nine-game postseason losing streak with a 24-23 win over the Rams on Wild Card Weekend almost two years ago. The Lions followed that up with a 26-20 overtime victory over Los Angeles in the 2024 season opener.

In the two contests against his former club, Stafford averaged 342 passing yards with 3 combined touchdowns and an interception. Meanwhile, Goff averaged 247 passing yards with 2 total TDs and a pick.

Can we all agree that Jahmyr Gibbs is easily the BEST runningback in the NFL? pic.twitter.com/yAuWK2TPLr

— 𝔗𝔥𝔢 𝔇𝔢𝔱𝔯𝔬𝔦𝔱 𝔗𝔦𝔪𝔢𝔰 📰 (@the_det_times) December 6, 2025

Los Angeles Rams vs Detroit Lions Picks

Both Detroit and Los Angeles' defenses are stout against the run and middling against the pass. However, Dan Campbell's club has been ravaged in the secondary with safety Brian Branch the latest to go down with a torn Achilles.

We'll take Sean McVay's Rams to cover the points (-5) against the Lions with the UNDER 54.

LA Rams to cover vs Lions