The San Francisco 49ers enter their Week 12 matchup on Thanksgiving Day against the Seattle Seahawks riding a two-game win streak. Can they nudge that run of victories to three? Or will they return to the downward slope of their roller coast season?
That’s the question everyone’s asking of the NFL’s premier Jekyll-and-Hyde act. We’ll get our answer on Thursday, November 23, in the NFL Thanksgiving Day showcase game. San Francisco 49 will be traveling to face the Seahawks in this one, on Lumen Field in Seattle, Washington. But if you think playing on the road will shift the latest NFL online betting odds in the Seahawks’ favor, think again:
Favorite 
Underdog San Francisco 49ers -295 +240 Seattle Seahawks
Like usual, please remember to double-check these online NFL betting odds until you actually submit your wager. Our 49ers vs. Seahawks Week 12 betting odds are accurate entering Tuesday, November 21. That gives the best NFL online betting sites plenty of time to make adjustments leading into opening kick-off on Thursday night.
The stakes are high entering Niners vs. Seahawks on Thanksgiving. Whichever team wins this game may be the odds-on favorite to win the NFC West. What’s more, the winner will likely see a significant boost in their odds to win the Super Bowl. It is, in fact, that time of year—a period in which every outcome is much more important than before. Which way should you bet for Seattle vs. San Francisco? Read on to find out.
Are the San Francisco 49ers Back to Being Elite?
San Francisco looked touch and go for a while. After opening the season 5-0, they lost three straight games, dropping to 5-3. Their competition wasn’t necessarily easy during that stretch. But they kept blowing games amid a haze of terrible offensive decisions.
The Niners have cleaned up a lot of their issues over the past two weeks. They dominated the Jacksonville Jaguars in Week 10, winning 34-3. And then they fended off a frisky Tampa Bay Buccaneers squad, hanging 27 points on one of the league’s more underrated defenses.
Traveling to face the Seahawks poses a different kind of test. Winning in Seattle is hard. Only one team has done it all season (Los Angeles Rams), and that was all the way back in Week 1. Yet, the Seahawks appear to be on the downswing. It isn’t just that they’ve lost two of three games. It’s more so that the passing attack has regressed. Seattle is now 12th in net yards per passing attempt, 15th in interceptions thrown and 18th in passing touchdowns—rankings that pale in comparison to where they were just a few weeks ago.
Squaring off against high-ceiling defenses also hasn’t been the Seahawks’ specialty. This will be their first matchup versus the Niners, but they have mustered 13 and 16 points, respectively, against the Rams. They dropped three points on the Baltimore Ravens just a couple of weeks ago. And they managed just 13 points versus the Cincinnati Bengals in Week 6.
The Niners’ offensive inconsistencies could open the door for Seattle to keep things close. But San Francisco’s defense will be the best that the Seahawks have encountered all year. That means more than their home-field advantage.
OSB Prediction: San Francisco 49ers (-295)
Don’t Count on NFL Point Spread Betting Trends to Save You When the Niners Travel to Face the Seahawks
The Niners and Seahawks have a combined record under .500 against the spread. No discernible trend bubbles to the surface when looking at how San Francisco fares on the road or Seattle fares at home, either. That’s makes parsing the latest Week 12 NFL point spread betting odds a lot harder:
- San Francisco 49ers, -7 (-104)
- Seattle Seahawks, +7 (-116)
Deciding on the 49ers vs. Seahawks point spread effectively comes down to one question: Which version of San Francisco's offense will show up? That’s been a tough query to answer over the past few weeks. One game, quarterback Brock Purdy looks like a dark horse MVP candidate. The next week, the Niners are committing three turnovers and unable to regularly move the chains.
Optimists will look at the 34 points and 27 points, respectively, that the Niners have dropped over the past two weeks as evidence that they’ve turned a corner. Typically, we’d want to see another week or two of high-scoring offense to agree. But San Francisco’s struggles coalesced with injuries. Both offensive tackle Trent Williams and wideout Deebo Samuel were missing time, and Christian McCaffrey was effectively playing hurt.
Well, Williams and Samuel are back. And while McCaffrey hasn’t found the end zone since Week 9, he’s racked up 245 total yards from scrimmage during that time. Picking the Niners to cover on the road against the Seahawks is a little risky. But our confidence level in them hasn’t been this high in over a month.
OSB Prediction: San Francisco 49ers, -7 (-104)
The Over/Under Betting Lines for 49ers vs. Seahawks Seem Like They Expect San Francisco’s Defense to Prevail
Any game featuring the Seahawks with an over/under line beneath 45 points is a genuine rarity. And yet, that’s exactly what’s being offered by the latest Week 12 NFL over/under betting odds:
- Over 42.5 (-112)
- Under 42.5 (-108)
This point total basically banks on the Niners shutting down the Seahawks offense. That’s…doable.
Seattle isn’t the same team that started off the year torching defenses. Though they’ve limited their turnovers over the past two weeks, they have still committed 10 combined giveaways over the past six games.
The pressure generated by San Francisco’s defense won’t do Seahawks quarterback Geno Smith any favors. The Niners are getting a sack on 9.92 percent of their defensive plays over the past three weeks—a top-five mark during that time. Seattle’s offensive line isn’t exactly a turnstile, but they have been wildly up-and-down. That’s enough to give the benefit of the doubt to San Francisco’s defense and, by extension, the “under.”
OSB Prediction: Over 42.5 (-108)
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