Defending Champions Sinner, Sabalenka Favored To Repeat In US Open Tennis

WHAT: US Open Tennis Championship
WHEN: Monday, August 18, 2025 - Sunday, September 8th, 2025
WHERE: New York, USA
WATCH: ESPN/ABC

Italy's Jannik Sinner and Belarusian Aryna Sabalenka are the defending champions in the US Open tennis championship. They are also the betting favorites to retain their titles.

Sinner is the even-money chalk to win the US Open men's singles title again. Sabalenka is the +250 favorite in the women's singles tournament.

Spain's Carlos Alcaraz (+180) and Serbia's Novak Djokovic (+1000) are other top contenders in the men's singles event.

Let's look at the latest US Open tennis betting lines. Remember, odds are always subject to change.

US Open Men's Singles Odds
Jannik Sinner	EVEN	-120	+100
Carlos Alcaraz	+180	+175	+190
Novak Djokovic	+1000	+800	+350
Jack Draper	+1400	+1400	+1200
Alexander Zverev	+1600	+1200	+850
Ben Shelton	+2000	+2000	+2200
Daniil Medvedev	+2200	+1600	+1600
Taylor Fritz	+2800	+2500	+2500
Jakub Mensik	+5000	+5000	+5000
Joao Fonseca	+5000	OFF	+4000
Holger Rune	+6600	+6600	+4000
Alex de Minaur	+6600	+6600	+6600
Tommy Paul	+8000	+6600	+6600
Casper Ruud	+8000	+8000	+6600
Frances Tiafoe	+8000	+6600	+4000

In women's singles competition, Iga Swiatek (+300), Coco Gauff (+450), and Mirra Andreeva (+800) also feature short odds.

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US Open Men's Singles Top Contenders

Banking on history repeating itself might not be the best bet when it comes to US Open men's singles wagering. You have to go back 16 years to when Roger Federer won five titles in a row from 2004 to 2008 to find a repeat champion.

Jannik Sinner (+120)

The Italian is 4-1 in Grand Slam finals, but he's 3-0 in Grand Slam finals played on hard courts.

a championship run to remember for Jannik Sinner. 🦊 pic.twitter.com/5TIcGdtu5K

— US Open Tennis (@usopen) August 16, 2025

In winning his second straight Australian Open title earlier this year, Sinner won the semifinal and final in straight sets.

Carlos Alcaraz (+200)

Alcaraz won the US Open title in 2022. In the last two years, he's lost in the second round and the semifinals.

Novak Djokovic (+1000)

Nursing a nagging groin injury, the 38-year-old veteran skipped last week's tour stop in Cincinnati. Djokovic is a four-time US Open champ, winning most recently in 2023.

Jack Draper (+1400)

Last year, the British player reached the semifinals of this event as the No. 25 seed. That's the only time Draper's been past the fourth round in 13 Grand Slam tournaments.

Alexander Zverev (+1600)

Zverev lost the 2020 men's singles final in this tournament to Dominic Thiem. The German player lost this year's Australian Open final to Sinner.

US Open Men's Singles Longshot Bets

Daniil Medvedev (+2200) won the US Open men's singles title in 2021 and was the losing finalist in 2019 and 2023. Taylor Fritz (+2800) lost last year's final.

Casper Ruud (+8000) lost the 2022 final. Stan Wawrinka (+50000) was the 2014 US Open men's singles winner.

And The Winner Is . . .

Sinner and Alcaraz have combined to win the past seven Grand Slam titles. Alcaraz won the French Open this year.

Jannik Sinner To win US Open men's singles

+EVEN

Bet Now!

However, when it comes to hard courts, it's Sinner who rules. Sinner has won the last three hard-court Grand Slams - the past two Australian Opens and this tourney last year. Bet him to defend his title in the US Open men's singles picks.

US Open Women's Singles Top Contenders

Four of the past eight winners of the US Open women's singles titles were first-time Grand Slam winners.

US Open Women's Singles Odds
Aryna Sabalenka	+250	+225	+250
Iga Swiatek	+300	+300	+300
Coco Gauff	+550	+600	+450
Maria Andreeva	+800	+900	+800
Elena Rybakina	+1200	+700	+1000
Amanda Anisimova	+1600	+1400	+1400
Naomi Osaka	+1600	+1600	+1600
Victoria Mboko	+1600	OFF	OFF
Madison Keys	+1600	+1800	+1600
Qinwen Zheng	+2000	+1400	OFF
Jessica Pegula	+2500	+1200	+2200
Barbora Krejcikova	+4000	+4000	+6600
Emma Raducanu	+4000	+2500	+3300
Emma Navarro	+4000	+2500	+3300
Belinda Bencic	+4000	OFF	OFF
Jasmine Paolini	+4000	+3300	+3300
Paula Badosa	+4000	+2500	+6600

Four of the last five US Open losing finalists have never won a women's singles title at Flushing Meadows.

Aryna Sabalenka (+250)

Sabalenka has three wins in the past 10 tennis Grand Slam events. Over that span, she's been a losing finalist three times and was eliminated in the semifinals on three occasions.

Your defending champ is back! 👀 pic.twitter.com/oqtbW50quy

— US Open Tennis (@usopen) August 17, 2025

Along with her win in last year's US Open, she was the losing finalist in 2023.

Iga Swiatek (+300)

The Polish player was the 2022 US Open women's singles champion. However, in the past two tournaments, Swiatek hasn't made it past the quarter-finals.

Coco Gauff (+450)

There always seems to be a home-court advantage for Gauff at Flushing Meadows. She won here in 2023, beating Sabalenka in the final.

Mirra Andreeva (+800)

World No. 5 Andreeva is still trying to make her mark in a Grand Slam event. She lost in the quarter-finals at Wimbledon and Roland Garros, and in the Round of 16 in Melbourne.

Elena Rybakina (+1200)

Rybakina has been ranked as high as No. 3 in the world. However, she's never made it past the third round in six US Open appearances.

US Open Women's Singles Longshot Bets

Canadian Open champion Victoria Mboko (+1600) will likely attract some action. Canadians have fared well of late in the US Open. Bianca Andreescu (+6600) won in 2019, while Leylah Fernandez (+6600) reached the 2021 final.

Jessica Pegula (+2500) was last year's losing finalist. Ons Jabeur (+6600) lost the 2022 final. Victoria Azarenka (+12500) lost the 2020 final to Naomi Osaka (+1600). Sloane Stephens (+15000) was the 2017 US Open women's singles champion, beating Madison Keys (+1600) in the final.

And The Winner Is . . .

Sabalenka is still seeking her first Grand Slam win of 2025. She lost in the finals of the Australian and French Opens and was ousted in the semifinals at Wimbledon.

Aryna Sabalenka To win US Open women's singles

+250

Bet Now!

The hard courts of Flushing Meadows suit the Belarusian's game to perfection. Go with Sabalenka to win in the US Open women's singles picks.