Inter Miami vs New York City FC Picks

What: New York City FC at Inter Miami
Where: Chase Stadium in Fort Lauderdale, Florida
When: Saturday, November 29th at 6:00 pm EST

Lionel Messi scored a goal and three assists in a 4-0 win over FC Cincinnati on Sunday to lead Inter Miami CF to its first-ever Eastern Conference final. Already with a MLS playoff record 12 goal contributions, the Argentinian legend will now host New York City FC with a spot in the 2025 MLS Cup on the line.

Let's look at the latest betting lines for Saturday's match. Odds are subject to change.

	Spread	Money Line	Total Points
Inter Miami	-1.0 (-115)	-182	Ov 3 (-102)
New York City FC	+1.0 (-105)	+400	Un 3 (-118)
Draw		+360

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Inter Miami vs New York City FC

Inter Miami (-181) is a home favorite over New York City FC (+400) in their single-elimination Eastern Conference Finals matchup. Lionel Messi seems determined to hoist his first MLS Cup. The 38-year-old has already set a new postseason record with six goals and six assists in four games.

In addition to Messi's four point performance in Sunday's 4-0 victory over FC Cincinnati, Tadeo Allende scored twice. If the Herons win again this Saturday, they'd host the MLS Cup on Dec. 6 at Chase Stadium. The OVER/UNDER is set at 3 total goals with the juice (-118) towards the UNDER.

LIONEL MESSI LOVES A BIG GAME. ✨

What a move to open the scoring! // Audi MLS Cup Playoffs pic.twitter.com/l0L3miaYYZ

— Major League Soccer (@MLS) November 23, 2025

Road warriors

New York City FC is 3-0 on the road this postseason. After winning twice in Charlotte in Round One, the Cityzens stunned the Philadelphia Union 1-0 in the Eastern Conference Semifinals. Maxi Moralez scored the lone goal and USMNT goalkeeper Matt Freese made five saves to eliminate the Supporters' Shield winners and advance NYCFC to their third Conference Final since 2021.

Freese has only allowed one goal in regulation time in the playoffs and already has three shutouts. Can he stop Messi from securing his first major trophy in the United States?

Matchup history

Inter Miami downed NYCFC 4-0 at Citi Field on Sept. 24, with Messi notching a goal and two assists, and the two teams played to a 2-2 tie way back in February.

NYCFC is undefeated in its last four trips to Chase Stadium, but their only victory was in a friendly. New York also downed a Gonzalo Higuaín-led Miami team 3–0 back in 2022 before Messi's arrival.

CLUTCH CLEAN SHEET from Matt Freese to send @newyorkcityfc to the Eastern Conference Finals! ❄️ pic.twitter.com/KaS7KmAs5l

— U.S. Soccer Men's National Team (@USMNT) November 24, 2025

While New York City looks like a difficult defensive matchup, don't forget that Cincinnati held Miami scoreless in both regular season meetings before Inter Miami walloped them 4-0 in the Conference Semifinals.

After scoring 11 goals in his last seven games, Messi will get another one to lead Inter Miami to victory -1.0 (-115) in regulation with the OVER 3 (-102).

Inter Miami to cover vs NYCFC