• What: UEFA Champions League Round of 16 Second Leg
  • Who: Arsenal vs Bayer Leverkusen
  • When: Tuesday, March 17, 2026, 4 p.m. ET
  • Where: Emirates Stadium
  • Watch: Paramount+/TUDN

Arsenal and Bayer Leverkusen are deadlocked heading into the second leg of their UEFA Champions League Round of 16 clash. The English Premier League leaders are coming home, though, and oddsmakers see that factor making all the difference as the two clubs meet again on Tuesday at Emirates Stadium.

On its home pitch, oddsmakers are setting Arsenal as overwhelming -370 favorites in the soccer odds to be winning the match and advancing to the quarterfinals. Bayer Leverkusen are massive +900 underdogs. The two clubs drew 1-1 in the first leg last week at BayArena.

Let’s look at the latest soccer betting lines for this match. Remember, the odds are always subject to change.

UEFA Champions League Round of 16 OddsThe PickBovadaBetUSBetOnline
Arsenal vs Bayer LeverkusenArsenal-370-350-340

In this article, OSB will review the match, predict the winner of the matchup, and provide additional notes and information on soccer picks and betting.

Best UEFA Champions League Betting Tips

Keep on top of the latest betting updates on UCL action by checking in with our UEFA Champions League page. If you're new to wagering on soccer, our soccer betting page is chock full of the best wagering advice and handy betting tips.

The UEFA Champions League is a months-long competition, but thanks to your mobile device, you'll never be more than moments away from placing your UCL wagers. Take advantage of the top mobile betting apps to place a bet wherever you might be in the course of your day.

Match Overview: Arsenal vs Bayer Leverkusen

Neither of these clubs has a sterling history in the UEFA Champions League. Arsenal reached the semifinals last year. That was the English side's best performance since also getting to the final four in 2008-09.

Bayer Leverkusen has never advanced beyond the quarterfinal stage in UCL competition.

Team Spotlight: Arsenal

An 89th-minute penalty by German international and former Leverkusen player Kai Havertz put Arsenal in a much better position to advance than if the club had come home from the first leg trailing 1-0 on aggregate. Arsenal substitute Noni Madueke was fouled in the box to draw the penalty.

Still, that 1-1 draw marked the first dropped point by the Gunners in UCL action. Arsenal went 8-0 to win the league stage of UEFA Champions League competition. The club produced a +19 goal differential.

Team Spotlight: Bayer Leverkusen

Robert Andrich's 46th-minute goal from a corner gave Bayer Leverkusen the lead in the first leg against Arsenal. It was the first time the Gunners had trailed in a UCL match this season.

In their past two matches, Leverkusen has drawn 1-1 with Arsenal and Bayern Munich. Those two clubs are the top betting picks to win the UEFA Champions League.

Bayer Leverkusen beat Greek side Olympiacos 2-0 to advance through the UCL playoff round. The German club won the away leg of that round by a 2-0 margin.

Best UCL Prop Bets

The soccer betting line on this match ending in a draw after 90 minutes of play is set at +500. The total goals for the game are set at 2.5. Play the over at odds of -122. Oddsmakers are assigning soccer betting odds of +102 to the under.

The soccer betting line is +150 that both teams will score during the match. Both teams to score in both halves offers a line of +1600 in this betting market. The second half is the -109 betting pick to be the highest-scoring half.

Arsenal by one goal is the +280 favorite in a winning margin soccer prop. In a correct score wager, Arsenal to win 2-0 is the +550 chalk.

The Gunners keeping a clean sheet is set with a soccer betting line of -114, and it's +150 that Arsenal records a shutout victory. It's +1200 that Bayer Leverkusen keeps a clean sheet.

Latest UEFA Champions League Futures

Current English Premier League leaders Arsenal are the chalk in this soccer future. The club is sitting at odds of +250 of becoming UEFA Champions League winners for the first time. Germany's Bayern Munich is next in the soccer betting line at odds of +500. As for Bayer Leverkusen, this German club is showing as a +12500 long shot to become the UCL winner.

Barcelona, a five-time UCL winner, is showing odds of +650 to win this season's title. The defending champions, PSG, are sitting as the +650 fourth choice on the soccer betting line.

Next at +800 are record 15-time UEFA Champions League winners Real Madrid. Following in the betting line are six-time winners Liverpool at +1000.

Best Bet To Win On UEFA Champions League Round of 16

Arsenal has won six straight matches at home. The club has allowed just three goals over those six matches, keeping four clean sheets. Arsenal has won three of the games by multiple-goal margins.

Arsenal To win UEFA Champions League Round of 16 Second Leg
Bovada
-370
Bet Now!

Bayer Leverkusen has played three straight draws and gone 0-2-1 in its past three away matches. It seems a tall order to expect the German side to win at the Emirates. Take Arsenal to win and advance to the quarterfinals in the UEFA Champions League picks.