Lionel Messi and Inter Miami favored to win 2025 MLS Cup

What: 2025 MLS Cup
Who: 30 Major League Soccer clubs
When: February - December, 2025

With the CONCACAF Gold Cup and FIFA Club World Cup in the rear-view mirror, Major League Soccer's contenders are back at full strength for the second half of the season. Before the transfer window opens up in just over a week, let's look at the latest betting lines for the 2025 MLS CUP. Odds are subject to change.

MLS Cup Winner
Inter Miami	+400	+400	+400
San Diego FC+	+700	+700	+700
Philadelphia Union	+900	+900	+900
Vancouver Whitecaps	+900	+900	+900
Columbus Crew	+1000	+1000	+1000
FC Cincinnati	+1000	+1000	+1000
Minnesota United	+1000	+1000	+1000
Los Angeles FC	+1200	+1200	+1200
Seattle Sounders	+1400	+1400	+1400
Nashville SC	+1600	+1600	+1600
Orlando City	+2500	+2500	+2500
Portland Timbers	+3300	+3300	+3300
New York City FC	+4000	+4000	+4000
Austin FC	+5000	+5000	+5000
Charlotte FC	+5000	+5000	+5000
Colorado Rapids	+5000	+5000	+5000
New York Red Bulls	+5000	+5000	+5000
Chicago Fire	+6600	+6600	+6600
San Jose Earthquakes	+6600	+6600	+6600
New England Revolution	+8000	+8000	+8000
Houston Dynamo	+10000	+10000	+10000
Real Salt Lake	+10000	+10000	+10000
Atlanta United	+20000	+20000	+20000
Sporting Kansas City	+20000	+20000	+20000
FC Dallas	+20000	+20000	+20000

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Inter Miami favored

Inter Miami is a +400 favorite to win the franchise's first MLS Cup. After capturing the Supporters' Shield with a new all-time points record during the 2024 regular season, Lionel Messi's club was eliminated in the first round of the playoffs by Atlanta United FC in one of the biggest upsets in league history.

This season, the Argentinian legend has set a new MLS record with goals in five straight games. Sitting in 5th place in the eastern conference with 3 games in hand, Inter is currently on a five-game win streak.

🇦🇷✨ 𝗢𝗡 𝗧𝗛𝗜𝗦 𝗗𝗔𝗬 𝟮 𝗬𝗘𝗔𝗥𝗦 𝗔𝗚𝗢: Lionel Messi signed for Inter Miami!

🏟️ 63 games
🌟 80 G/A
⚽️ 54 goals
🅰️ 26 assists
🎁 2 penalties
🎯 6 free kick goals
🏆 2 trophies won pic.twitter.com/0GnoKjxoLI

— The Touchline | Football Coverage (@TouchlineX) July 15, 2025

On top of the tables

San Diego FC (+700) is the top team in the Western Conference thanks to new arrival Anders Dreyer. The 27-year-old Danish star has the most goals (11) and assists (13) in the league. He's also one of only five players to make 26 goal contributions in his club's first 22 games in MLS history.

Philadelphia (+900) lead the Supporters' Shield standings with 43 points. This is the best Union squad since the 2022 team that averaged 1.97 points per game. This year's group is averaging 1.95 and they just added Tai Baribo and Quinn Sullivan back in the mix.

Intriguing longshots

Minnesota United (+1000) is second place in the West and sixth in the Shield standings despite averaging the lowest possession in the league. The Loons make up for it by scoring the most set-piece goals per game (0.41) in the MLS.

Columbus (+1000) and FC Cincinnati (+1000) both look capable of bringing the MLS Cup to the state of Ohio. The Crew scored four unanswered goals to defeat their state rivals 4-2 in the latest Hell is Real derby.

Another two goals from Anders Dreyer today.

He has become the third player in MLS history to record at least 10 goals and 15 assists in his debut season.

🇩🇰💪 pic.twitter.com/xp5EwaZSPr

— Danish Scout (@DanishScout_) July 13, 2025

2025 MLS Cup Winner Picks

Nashville SC (+1600) is coming off a 2-1 defeat to Inter Miami thanks to a massive second-half gaffe by goalkeeper Joe Willis. However, they were riding a 15-game unbeaten streak and outplayed their opponents for much of the match. At +1600 to win the MLS Cup, Nashville is a screaming value.

Nashville to win MLS Cup

+1600

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