Tennis Betting Picks & Prediction for the 2021 US Open

Eric Uribe
By , Updated on: Sep 4, 2022 08:00 PM
Tennis Betting Picks & Prediction for the 2021 US Open

Summer is winding down, which typically doesn't make people feel great. On the bright side, it means something awesome for tennis fans: The U.S. Open is back! 

While qualifying matches are still being played for the big event, the meat and potatoes of the field is set. And that invites tennis betting odds and picks for the 2021 U.S. Open immediately.

Our focus for this year's tournament will focus solely on the outright winners from the men's and women's brackets. To give you a complete picture of all your options, we've culled the latest 2021 U.S. Open betting odds from BetOnline.

Here are the tenning betting lines on who will win the men's bracket:

Pick to WinBetOnline
Novak Djokovic-150
Daniil Medvedev+400
Alexander Zverev+550
Stefanos Tsitsipas+800
Matteo Berrettini+2500
Milos Raonic+3300
Andrey Rublev+4000
Jannik Sinner+4000
Denis Shapovalov+5000
Andy Murray+6600
Aslan Karatsev+6600
Felix Auger Aliassime+6600
Karen Khachanov+6600
Hubert Hurkacz+8000
Nick Kyrgios+8000
Pablo Carreno-Busta+8000
Sebastian Korda+8000
Casper Ruud+10000
John Isner+10000
Reilly Opelka+10000
Roberto Bautista-Agut+10000
Alex De Minaur+15000
David Goffin+15000
Diego Schwartzman+15000
Gael Monfils+15000
Grigor Dimitrov+15000
Marin Cilic+15000
Ugo Humbert+15000

And here are U.S. Open betting lines for who will win the women's bracket:

Pick to WinBetOnline
Ashleigh Barty+350
Naomi Osaka+500
Aryna Sabalenka+900
Serena Williams+900
Bianca Andreescu+1200
Iga Swiatek+1200
Cori Gauff+1600
Karolina Pliskova+1600
Simona Halep+1600
Barbora Krejcikova+2000
Garbine Muguruza+2000
Belinda Bencic+2500
Jennifer Brady+2500
Petra Kvitova+2500
Victoria Azarenka+2500
Angelique Kerber+3300
Danielle Collins+3300
Elena Rybakina+3300
Karolina Muchova+3300
Maria Sakkari+3300
Ons Jabeur+3300
Paula Badosa+3300
Sofia Kenin+3300
Camila Giorgi+4000
Elise Mertens+4000
Jessica Pegula+4000
Anastasia Pavlyuchenkova+5000
Madison Keys+5000
Marketa Vondrousova+5000
Sloane Stephens+5000
Jil Teichmann+6600
Amanda Anisimova+8000
Daria Kasatkina+8000
Jelena Ostapenko+8000
Liudmilla Samsonova+8000
Anastasia Potapova+10000
Emma Raducanu+10000
Johanna Konta+10000
Leylah Fernandez+10000
Sara Sorribes Tormo+10000

As usual, please confirm these tennis odds before picking your outright U.S. Open winner. There is still plenty of time to go until the start of the tournament and things change as it unfolds, so these lines will shift at BetOnline and other top online sportsbooks.

2021 US Open Betting Breakdown

  • When: Monday, August 30 - Sunday, September 12
  • Where: USTA Billie Jean King National Tennis Center in Flushing, New York
  • Surface: Hard court
  • 2020 Men's Winner: Dominic Thiem
  • 2020 Women's Winner: Naomi Osaka

2021 U.S. Open Men's Prediction

us open mens odds

The men's field at the 2021 U.S. Open is either priming us for a bunch of surprises or a mostly non-eventful run. Not only is the reigning champion, Dominic Thiem, unable to participate due to a wrist injury, but both superstars Rafael Nadal, who won the 2019 U.S. Open, and Roger Federer, who once won five straight U.S. Open titleswon't be in the bracket either thanks to injuries of their own.

This seemingly paves the way for Novak Djokovic (-150) to win it all—and do so rather easily. He hasn't historically been a no-brainer pick at the U.S. Open during his time as the world's No. 1. He has three title to his resume—2011, 2015, 2018—but has never won back-to-back championships and has suffered many unexpected upsets.

Again: This year might be wildly different. Oddsmakers have pegged his greatest challengers as Daniil Medvedev (+400)Alex Zverev (+550) and Stefanos Tsitsipas (+800). No one else has even been billed as a remote option. The fifth-best betting odds belong to Matteo Berrettini (+2500), and he's laying 25-to-1.

Seeing someone so heavily favored this early into the equation is borderline unprecedented. Even prime Federer used to have more than a couple of opponents inside 10-to-1 territory. Djokovic isn't just a favorite; he's essentially the only viable outright pick at this juncture.

Far be it from us to shirk that trend. He's currently landing 65 percent of all his monster first serves and wins those first serves 75 percent of the time. Maybe an Andy Murray (+6600) or Nick Kyrgios (+8000) sneaks themselves into this discussion if they get hot, but for now, we don't see a realistic path to anyone upsetting the world's No. 1.

OSB U.S. Open Men's Prediction: Novak Djokovic (-150)

Novak Djokovic To win the 2021 U.S. Open

2021 U.S. Open Women's Prediction

US open women odds

Figuring out the women's bracket at the U.S. Open is a far more interesting proposition. Ashleigh Barty (+350), the world's current No. 1, is pegged as the favorite, but she's paying out far more than even money.

And whereas the men have just four total players laying better than +2000 lines, the women's bracket has eight names in that territory on top of Barty: reigning champion Naomi Osaka (+500), Aryna Sabalenka (+900), Serena Williams (+900), Bianca Andreescu (+1200), Iga Swiatek (+1200), Cori Gauff (+1600), Karolina Pliskova (+1600) and Simona Halep (+1600).

Many bettors like to gravitate towards the reigning women's champion, which would be Osaka in this case. That's not a bad bet. But she has not been at the top of her game this season, largley becauase she's battling stress and anxiety by her own admission. We don't dissuade you from picking her; she is the future of tennis. But there is a risk.

Rolling with Barty is of course perfectly fine. She has earned the world's top spot, winning over 81 percent of her service games. You won't catch any flak from us if you want to invest in the greatest of all time, Serena Williams, either.

For our money, though, we are incredibly intrigued by Gauff. She can be a little erratic, which accounts for her No. 22 world ranking. But she's starting to pick up her play of late. She's now dropping in more than 60 percent of her first serves and winning nearly 67 percent of all her service games. Oddsmakers have touted her as a dark horse-candidate. We believe she's something much more dangerous. 

OSB U.S. Open Women's Prediction: Cori Gauff (+1600)

Cori Gauff To win the 2021 U.S. Open

Check out this list of the top online sportsbooks so you can decide which one to use for all your tennis betting:

Meet the author

Eric Uribe

Eric has been passionate about sports since he was 10 years old. He brings over 10 years of sports journalism experience to his expert coverage of sports betting. Hailing from the US, Eric leverages his diverse expertise covering sports at all levels – from high schoo...

Online Sports Betting may receive compensation if you sign up through our links. Rest assured, we avoid biases and provide honest opinions on sportsbooks. Read more here.