All across best online NFL betting sites, the Buffalo Bills are heavily favored over the Minnesota Vikings entering their Week 10 matchup on Sunday, November 13, at 1 p.m. EST. While that makes sense on its face, we're here to tell you that, this time, it's wrong.
Indeed, the Bills have been one of the primary Super Bowl favorites all season. But the Vikings have just one loss themselves, and they haven't incurred a letdown since Week 2. Oh, and on top of that, Buffalo is evaluating star quarterback Josh Allen for a UCL injury he may have suffered during Week 9. If he's not able to go or he's trying to play at less than full strength, that will inherently open the door for Minnesota.
Before we go any further, though, let's have a look at the latest NFL online betting odds for Buffalo Bills vs. Minnesota Vikings:
| Favorite |  | | Underdog |
|---|---|---|---|
| Buffalo Bills | -270 | +220 | Minnesota Vikings |
Please remember to double-check these online NFL betting odds right up until you place your wager. This is especially true for Vikings vs. Bills betting odds. Linemakers will make changes through opening kickoff, and they will obviously react to any breaking news on Allen's injury. For reference, our NFL betting odds are accurate entering Tuesday, November 8, so you'll want to refresh them if you're placing your bet thereafter.
Meanwhile, if you're still in the market for a place to bet on the NFL, consider checking out our reviews of the top online sportsbooks. We've compiled all the information you could ever need to find the best NFL online betting sites in 2022.
And with all of that said, should you bet on the Vikings to upset the juggernaut Bills? Let's explore.
Minnesota Vikings Have the Juice to Upset the Buffalo Bills in Week 10
There is no other team in the NFL that rivals the two-way dominance of the Bills. Buffalo ranks third in points scored per game and first in points allowed per game. Many questioned why so many sites gave them the best odds to win the Super Bowl entering this season. We were among the skeptics. And we're not anymore.
Still, the Bills do not enter this Week 10 matchup in great shape. Quarterback Josh Allen suffered a UCL injury during Buffalo's Week 9 loss to the New York Jets, and while the Bills have yet to give an official prognosis, the early indications aren't great.
In fact, at this moment, our expectation is that Josh Allen won't play against the Vikings. That changes everything for the Bills. Backup Case Keenum is more than capable, and Buffalo is fifth in net yards per rushing attempt on the ground, but Allen is very much the engine that makes the offense go. Without him, they cannot hope to hang with competent squads.
News flash: The Vikings are a competent squad. They enter Week 10 placing in the top 12 of both points scored and allowed per game. Doubters will immediately gesture toward their relatively easy schedule, which has seen them beat just one team over .500 on the year. But picking up victories against the Arizona Cardinals (Week 8) and Miami Dolphins (Week 6) isn't easy.
Heck, Minnesota might be a threat to win this one even if Josh Allen plays. The Vikings are seventh in red zone scoring percentage and do a great job converting their fourth down attempts. Quarterback Kirk Cousins is once again playing like he belongs in the Pro Bowl, and Minnesota ranks in the top 10 of both scoring and rushing touchdowns on the season. This is a great opportunity to capitalize on a lopsided line while you can.
OSB Prediction: Minnesota Vikings (+220)
Jump on the Vikings to Cover the Point Spread Against the Bills While You Can
Below you can find the latest NFL point spread betting odds for Bills vs. Vikings:
- Buffalo Bills, -6.5 (-110)
- Minnesota Vikings, +6.5 (-110)
Betting on the Vikings point spread is a good way to hedge your investment. Even if Allen plays, and even if Minnesota loses, this game should still be close. The Vikings have one of the best run defenses in the game right now, and though their secondary is filled with cracks, they've managed to bag more interceptions than 27 other teams.
To be sure, Buffalo is no stranger to blowing out opponents at home. But with Allen mega questionable to play and the weather getting colder, we don't expect to see this on by an entire touchdown.
OSB Prediction: Minnesota Vikings, +6.5 (-110)
The Over for Minnesota vs. Buffalo Looks Enticing...For Now
Here are the latest NFL over/under betting odds for Vikings vs. Bills:
- Over 45.5 (-112)
- Under 45.5 (-108)
This line becomes a no-brainer if Josh Allen plays for Buffalo. He and Kirk Cousins would be destined to get in an air-it-out contest before the second half.
It's a different story if Allen doesn't play. We lean toward the over anyway. The Bills will let Case Keenum throw it enough to move the chains, and Kirk Cousins has Minnesota averaging around 27.2 points per game over their last six appearances.
Some bettors tend to shy away from the over when dealing with games in cold-weather climates. You don't have to worry about that here. It isn't expected to be that cold in Buffalo, and even if it is, the Vikings are just as familiar playing in extreme conditions as the Bills.
OSB Prediction: Over 45.5 (-112)
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