Chiefs vs Colts Picks | 11-23-25 | Online Sports Betting

What: Indianapolis Colts at Kansas City Chiefs
Where: Arrowhead Stadium
When: 1:00 PM EST, Sunday, November 23rd, 2025

Patrick Mahomes and the Chiefs are in danger of missing the playoffs following a 22-19 defeat to their division rivals in Denver. After winning 11 one-score contests last season, Kansas City has lost all five of their games by one score this year.

On Sunday, Andy Reid's club will try and get back on track against Jonathan Taylor and the 8-2 Colts. Let's look at the latest betting lines. Odds are subject to change.

	Spread	Money Line	Total Points
Indianapolis Colts	+3.0 (+100)	+155	Ov 49.5 (-115)
Kansas City Chiefs	-3.0 (-120)	-180	Un 49.5 (-105)

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Chiefs favored at Arrowhead

Kansas City is a 3-point home favorite at Arrowhead on Sunday. Not so long ago, Andy Reid's club was on a three-game winning streak and looking Super Bowl bound for the third-consecutive year.

However, following back-to-back losses to Buffalo and Denver, the Chiefs' run of nine straight AFC West titles is all but over. At 5-5, even a playoff spot isn't guaranteed as they're sitting ninth in the conference with seven games remaining.

Mahomes is picked! Denver takes over! #BroncosCountry

pic.twitter.com/ETP1epXzA0

— Matty B (@mattthew_jordan) November 16, 2025

Colts coming off a bye

The OVER/UNDER for Sunday's contest is set at 49.5 points. Indianapolis is the highest scoring team in the NFL (32.1) while the Chiefs rank 9th (25.4). Before his club's week 10 bye, Jonathan Taylor rushed for 244 yards and three touchdowns in a 31-25 victory over Atlanta.

After starting the season red hot, Daniel Jones tossed three interceptions and fumbled twice in a 27-20 loss to Pittsburgh in Week 9. The journeyman QB followed that up with another interception and three fumbles in the win over the Falcons. Luckily for Indiana Jones however, two of his fumbles were recovered by his teammates.

Taylor dominant on the ground

Steve Spagnuolo's defense is ninth versus the run, permitting 100 yards per game exactly. Will they be able to stop the NFL's rushing leader on Sunday? Taylor tops the league in both rushing yards (1,139) and rushing TDs (15) heading into Week 12.

Following a frustrating day in Denver, Mahomes will be looking to take advantage of an Indianapolis pass defense that ranks in the bottom ten (235.3 yards allowed per game). However, a lot of that damage was inflicted before the Colts sold the farm for cornerback Sauce Gardner at the trade deadline.

Players with 7,000+ rush yards and 70+ touchdowns prior to turning 27 years old:

HOF Emmitt Smith
HOF Jim Brown
HOF LaDainian Tomlinson
>Jonathan Taylor#ForTheShoe pic.twitter.com/ZO5kiL6ao5

— NFL+ (@NFLPlus) November 9, 2025

Kansas City Chiefs vs Indianapolis Colts Picks

If you like the Colts on Sunday, you should wait to place your bets as the line looks to be moving in KC's direction. That's why we'll lock in the Chiefs (-3) with the UNDER 49.5. While this has been a tough year in Kansas City, we can't see Patrick Mahomes falling under .500 on his home field.

Kansas City to cover vs Colts

-3.0

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