Think three straight losses will prevent NFL oddsmakers from favoring the San Francisco 49ers in their Week 10 matchup vs. the Jacksonville Jaguars? Think again.
Here are the latest NFL online betting odds for Niners vs. Jaguars, which will kick off on Sunday, November 12, at 1 p.m. eastern standard time, on the field at TIAA Stadium in Jacksonville, Florida:
Favorite 
Underdog San Francisco 49ers -166 +140 Jacksonville Jaguars
Remember to double-check these online NFL betting odds until you actually submit your wager. Our Jaguars vs. 49ers Week 10 betting odds are accurate entering Wednesday, November 8. That allows the best NFL online betting sites to adjust their lines depending on how the markets shake out in advance of opening kick-off on Sunday afternoon.
And speaking of which, it would not shock us to see movement here. While the Niners are not playing through the easiest stretch, their offense has looked inexplicably awful during this losing streak. San Francisco has tallied just 17 points in each of their past three games while committing a grand total of seven turnovers. Meanwhile, the defense is giving up nearly 400 total yards of total offense per week during this span.
Is it time to sound the alarm for the 49ers, who enter Week 10 clinging to the NFC West division lead? Or will they be able to pull out a victory against a Jaguars team that, believe it or not, currently has a better record than them?
Are We Sure the San Francisco 49ers Should be Favored to Beat the Jacksonville Jaguars?
The one word answer to this question: No. The in-depth response is more complicated.
Yes, the Niners continue to look on paper. But the past three weeks have anyone who invested in San Francisco’s betting lines to win the Super Bowl running scared. It isn’t just that they lost three straight. It’s that the Niners lost three straight games while delivering so many fundamental failures.
Chief among the disappointments: The offense. Quarterback Brock Purdy has turned into a turnover machine, and an oblique injury to star running back Christian McCaffrey has significantly diminished his versatility. San Francisco, not surprisingly, has generated more than 325 yards in total offense just once during this stretch. However, even if their offense is on, there’s no guarantee the 49ers defense picks up the slack.
Sure, they rank 4th in points allowed per game and also rank sixth in net yards allowed per pass attempt. San Francisco has also allowed 30 points just once all season—and they didn’t surrender it until Week 9. Still, the Niners have started to cede more ground through the air. In their last two games against the Cincinnati Bengals and Minnesota Vikings, they gave up more than 600 total passing yards.
Make no mistake, there’s a chance quarterback Trevor Lawrence and the Jaguars offense have a field day this week. San Francisco’s secondary can be almost impassable at their best, but the defense has ranked on the lower rung in sacks per game. Lawrence should at the very least have the time to survey the field and make plays. So, given the Niners’ recent struggles, we’re calling for an “upset.”
OSB Prediction: Jacksonville Jaguars (+140)
Jacksonville’s Point Spread Allows 49ers vs Jaguars Bettors to Hedge Nicely
If you aren’t quite sold on betting the Jaguars moneyline, you should consider the latest NFL Week 10 point spread betting lines:
- San Francisco 49ers, -3 (-112)
- Jacksonville Jaguars, +3 (-108)
Typically, we aren’t fans of sub-five-point spreads in general. But the 49ers’ slumping offense and Jacksonville’s own offensive inconsistency lends itself to close margins.
Plus, at 6-2, the Jaguars are tied with the Detroit Lions for the best record against the spread on the season. On top of that, two of the past three Niners games have been determined by five points or less.
More than anything, though, we just trust this Jaguars turnaround. Lawrence isn’t always good for statistical fireworks, but Jacksonville has topped 30 points in two of their past three games. All the while, Lawrence continues to display a profound knack for moving the chains off scrambles. That should prove to be a weapon for the Jaguars. For as good as the Niners defense has been, they can struggle to contain the most mobile quarterbacks.
And if that doesn’t do it for you, it’s time to trust the Jaguars defense. No team is forcing turnovers on a higher share of their defensive drives, and Jacksonville has allowed more than 21 points just once all season. And it has not happened since Week 3. When you consider the Jaguars defense will get to face the suddenly mistake-prone Purdy, you start to wonder why San Francisco is favored at all.
OSB Prediction: Jacksonville Jaguars, +3 (-108)
Defense Could be the Star of Niners vs Jaguars
The latest Week 10 NFL over/under betting lines do not expect San Francisco vs. Jacksonville to be a low-scoring affair:
- Over 46.5 (-110)
- Under 46.5 (-110)
We understand the appeal offered by the “over.” Both the Niners and Jaguars offenses rank in the top 10 of points scored per game and in the top 12 of net yards gained per pass attempt. San Francisco and Jacksonville each have the potential to light it up.
But the defenses have proven to be far more consistent. For the Jaguars, Lawrence doesn’t always rack up enough yards to promise 21-plus-point days. And for the Niners, Purdy has thrown an interception on what feels like every other drive over the past three weeks. He will now face one of the more aggressive secondaries in the league.
Of course, we must all recognize this game has the potential to finish with a total rising above 60 points. But that possibility wilts in the face of the defense on both sides. San Francisco remains an elite defense, and Jacksonville’s attack has only tightened up as the schedule wears on.
OSB Prediction: Over 46.5 (-110)
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